PHARMACEUTICAL ORGANIC CHEMISTRYII

( 3 units)

 

PCH 302 Mr. E. O. Afolabi's Lectures 1997/98 SESSION
3/3/1999

TOPICS:

wpe4.gif (897 bytes) Elimination Reactions:
Mechanism, Orientation, Scope and Limitation,

(Effect of substrate, Leaving group and Solvent)

ii. Applications

 

wpe5.gif (897 bytes)  Addition Reactions:

I. Addition to Carbon-Carbon multiple bonds.

ii. Addition to other conjugated multiple bonds.

iii. Addition to carbon-hetero multiple bonds.

 

wpe6.gif (897 bytes) Rearrangement Reactions:

wpe7.gif (897 bytes) Synthetic Methods in Medicinal Chemistry:

Carbon-Carbon forming reactions: Introduction.

(Functional group reactions and applications to

synthesis of organic compounds with examples

from biologically active compounds.)

PRACTICAL:

1. PREPARATION OF DIBENZALACETONE

2. PREPARATION OF NITRONAPHTALENE

3. PREPARATION OF BENZOIC ACID

CONTINUOS ASSESSMENT TEST:

March 17, 1999, (12:00-1:00) p.m.)

TEXT BOOK:

1. A Guidebook to Mechanism in Organic Chemistry

by Peter Sykes

2. Advanced Organic Chemistry

by Jerry March

SUPPLEMENTARY READINGS:

1. Morrison and Boyd

2. Finar Vol.1.

3. Geisman, T. A.

4. SCHAUM Outline ORGANIC CHEMISTRY

5. Carey, F. A.

6. Scudder P. H. Electron Flow in Organic Chemistry

7. Tewari, K. S.; Mehrotra, S. N.; and Vishnoi, N. K.

8. Pine, S.

9. Solomons, T.

10. Any other undergraduate text for Organic Chemistry

.