John T. Harty, Ph.D.
Ph.D., University of Minnesota, 1989 |
Carver College of Medicine Endowed Professor in Microbial Immunology Campus address: 3-512 BSB Mailing address: 51 Newton Rd. 3-512 Bowen Science Building Iowa City, IA 52242 Phone: 319-335-9720 Email: |
T cell responses to infection
In my laboratory we combine cellular and molecular approaches to dissect T cell mediated resistance to pathogens. Specifically, we use murine infection with Listeria monocytogenes, a bacterial pathogen or lymphocytic choriomeningitis virus, as model systems to understand the biology of CD8+ T cell mediated immunity to infection. We are also studying the factors that determine CD8 T cell mediated immunity against liver-stage malaria infection. Current projects involve:
1. Regulation of memory T cell development
2. Effector mechanisms of CD8 T cells in whole animal models of infectious disease
3. T cell homeostasis in response to infection.
4. T cell mediated immunopathology after virus infection
5. CD8 T cell immunity against live-stage malaria
Recent publications
Schmidt, N.W., R.L. Podyminogin, N.S. Butler, B.J. Tucker, A. Reyes-Sandoval, C.L. Hutchings, A.C. Moore, S.C. Gilbert, A.V. Hill, L.C. Bartholomay, and J.T.Harty (2008) Memory CD8 T cell responses exceeding a large, but definable threshold provide long-term immunity to malaria. Proceedings of the National Academy of Sciences, 105:14017-14022.
Harty, J.T. and V.P. Badovinac (2008) Shaping and reshaping CD8 T cell memory. Nature Reviews Immunology, 8:107-19.
Badovinac, V.P., J.S. Haring, and J.T. Harty (2007) Initial T cell receptor transgenic cell precursor frequency dictates critical aspects of the CD8 T cell response to infection. Immunity, 26: 827-841.
Jabbari, A. and J.T. Harty (2006) Secondary memory CD8 T cells are more protective but slower to acquire a central memory phenotype. Journal of Experimental Medicine, 203:919-932.