John T. Harty, Ph.D.
Ph.D., University of Minnesota, 1989 |
Mark Stinski Chair in Microbial Immunology Campus address: 3-530 BSB Mailing address: 51 Newton Rd. 3-530 Bowen Science Building Iowa City, IA 52242 Phone: 319-335-9720 Email: |
T cell responses to infection
In my laboratory we combine cellular and molecular approaches to dissect T cell mediated resistance to pathogens. Specifically, we use murine infection with Listeria monocytogenes, a bacterial pathogen or lymphocytic choriomeningitis virus, as model systems to understand the biology of CD8+ T cell mediated immunity to infection. We are also studying the factors that determine CD8 T cell mediated immunity against liver-stage malaria infection. Current projects involve:
1. Regulation of memory T cell development
2. Effector mechanisms of CD8 T cells in whole animal models of infectious disease
3. T cell homeostasis in response to infection.
4. T cell mediated immunopathology after virus infection
5. CD8 T cell immunity against liver-stage malaria
Recent publications
Butler, N.S., N.W. Schmidt, A.M. Vaughan, A.S. Aly, S.H.I. Kappe, and J.T. Harty (2011) Superior anti malarial immunity after vaccination with late-liver-stage arresting genetically attenuated parasites. Cell Host and Microbe. 9: 451-462. PMCID: PMC3117254
Nolz, J.C. and J.T. Harty (2011) Protective Capacity of Memory CD8 T Cells is Dictated by Antigen Exposure History and Nature of the Infection. Immunity. 34: 781-793. PMCID: PMC3103642.
Schmidt, N.W., N.S. Butler, V.P. Badovinac, and J.T. Harty (2010) Extreme CD8 T-cell requirements for anti-malarial liver-stage immunity following whole-parasite vaccination. PLOS Pathogens. 6: e1000998. doi:10.1371/journal.ppat.1000998 PMCID: PMC2904779
Wirth, T.C., D. Rai, J.T. Sabel, T. Bair, H.-H. Xue, J.T. Harty, and V.P. Badovinac (2010) Stepwise transcriptosome diversification in repetitively stimulated memory CD8 T cells. Immunity. 33:128-40. PMCID: PMC2912220