Abstracts

21st Annual CBB Conference "Current Topics in Industrial Biotechnology"

October 15-16, 2012
University of Iowa
Iowa Memorial Union, Iowa City, IA

Please check back later for 2012 conference poster information

20th Annual CBB Conference Poster Abstracts

EFFECT OF A MUTANT WITH ALTERED DYNAMICS ON HYDRIDE TRANSFERS CATALYZED BY THYMIDYLATE SYNTHASE
Thelma Abeysinghe, Zhen Wang and Amnon Kohen*
Department of Chemistry, College of Liberal Arts and Sciences, The University of Iowa, Iowa City, IA 52242
ROLE OF HOMOLOG CuZnSOD IN VIRAL PROPAGATION
Bhakti Bapat and David Murhammer*
Department of Chemical and Biochemical Engineering, College of Engineering, The University of Iowa, Iowa City, IA 52242
MATERIALS-BASED APPROACH TO IMPLANT INFECTION MITIGATION
Ann Baumhoer and Eric Nuxoll*
Department of Chemical and Biochemical Engineering, College of Engineering, The University of Iowa, Iowa City, IA 52242
SYNTHESIS OF N-ARYLACYL O-SULFONATED AMINOGLYCOSIDES THAT BIND HEPARAN SULFATE BINDING PROTEINS
Ioana Craciun, Amanda M. Fenner and Robert J. Kerns*
Division of Medicinal and Natural Products Chemistry, College of Pharmacy, The University of Iowa, Iowa City, IA 52242
ENHANCING GENE DELIVERY THROUGH NUCLEAR TARGETED PLA2
Samuel T. Crowley, Nick Baumhover and Kevin G. Rice*
Division of Medicinal and Natural Products Chemistry, College of Pharmacy, The University of Iowa, Iowa City, IA 52242
MULTICELLULAR DEVELOPMENT IN MYXOCOCCUS XANTHUS REQUIRES THE PUTATIVE FATTY ACID DESATURASE DES7
Cynthia Darnell and John Kirby*
Department of Microbiology, Roy J. and Lucille A. Carver College of Medicine, The University of Iowa, Iowa City, IA 52242
BIOCATAYTIC PRODUCTION OF XYLITOL FROM CORN STOVER HEMICELLULOSE HYDROLYSATE AND PURIFICATION OF THE PRODUCT BY SMB CHROMATOGRAPHY
Shuvendu Das¹, Michael Louie¹, Naveen Sudharsan², Anil Oroskar² and Venkiteswaran Subramanian¹*
¹Center for Biocatalysis and Bioprocessing, The University of Iowa Research Park, Coralville, IA 52241
²Orochem Technologies Inc.1, Lombard, IL 60148
EVALUATION OF qPCR PRIMERS TO DETECT METHANOTROPHS IN CONTAMINATED GROUNDWATER
Meredith L Dobson, and Timothy E Mattes*
Department of Civil and Environmental Engineering, College of Engineering, The University of Iowa, Iowa City, IA 52242
MICROGLIA AND A DOPAMINE-DERIVED NEUROTOXIN, 3,4-DIHYDROXYPHENYLACETALDEHYDE: TOXICITY, METABOLISM, ACTIVATION, AND IMPLICATIONS FOR PARKINSON’S DISEASE
Laurie L. Eckert, Virginia R. Florang, Jonathan A. Doorn*
Division of Medicinal and Natural Products Chemistry, College of Pharmacy, The University of Iowa, Iowa City, IA 52242
INVESTIGATING THE IMPACT OF METHYL – HYDROGEN EXCHANGE ON SUPRAMOLECULAR SOLID-STATE SELF-ASSEMBLY AND REACTIVITY: DIRECTED STEREOSPECIFIC PHOTOCYCLOADDITIONS OF TRISUBSTITUTED OLEFINIC ESTERS
Elizabeth Elacqua, Joseph C. Sumrak, Paul T. Jurgens, Bradley Loren, Poonam Kaushik, Ryan Groeneman, Dejan-Krešimir Bucar and Leonard R. MacGillivray*
Department of Chemistry, College of Liberal Arts and Sciences, The University of Iowa, Iowa City, IA 52242
THE SOLID PHASE SYNTHESIS OF REDUCIBLE POLYPEPTIDES
Mark D. Ericson and Kevin Rice*
Division of Medicinal and Natural Products Chemistry, College of Pharmacy, The University of Iowa, Iowa City, IA 52242
ENGINEERING OF CHLORELLA VULGARIS FOR BIOCATALYSIS TO GENERATE HIGH VALUE PRODUCTS
Todor Genkov, Michael Louie and Mani Subramanian*
Center for Biocatalysis and Bioprocessing, The University of Iowa Research Park, Coralville, IA 52241
COMPARISON OF PURIFICATION OF RECOMBINANT N-DEMTHYLASE B (NdmB) USING SIMULATED MOVING BED AFFINITY CHROMATOGRAPHY (SMB) AND FPLC
Juan Antonio Moreno-Cid Mora¹, Jingying Xu², Sridhar R. Gopishetty² and Mani Subramanian²,³*
¹Dpto. De Sanidad Animal, Instituto de Investigaciones en Recursos Cinegéticos, IREC, Ronda de Toledo, Spain
²Center for Biocatalysis and Bioprocessing, The University of Iowa Research Park, Coralville, IA 52241
³Department of Chemical and Biochemical Engineering, College of Engineering, The University of Iowa, Iowa City, IA 52242
SYNTHESIS OF PICOLYL AZIDE ANALOGUES OF NICOTINAMIDE AS POTENTIAL TWO-DIMENSIONAL INFRARED PROBES OF NAD(P)-DEPENDENT ENZYME DYNAMICS
Qi Guo, Philip Pagano, Christopher Cheatum* and Amnon Kohen*
Department of Chemistry, College of Liberal Arts and Sciences, The University of Iowa, Iowa City, IA 52242
IDENTIFYING OPTIMAL CONDITIONS FOR DETECTING VARING CONCENTRATIONS OF ATRAZINE USING RAMAN SPECTROSCOPY
Victoria A. Henry, Julie L. Jessop* and Tonya L.Peeples*
Department of Chemical and Biochemical Engineering, College of Engineering, The University of Iowa, Iowa City, IA 52242
4-HNE AND CCG-4986 COVALENTLY MODIFY RGS4 AT CYS148 TO ALLOSTERICALLY DISRUPT G PROTEIN BINDING
Colin A. Higgins and David L. Roman*
Division of Medicinal and Natural Products Chemistry, College of Pharmacy, The University of Iowa, Iowa City, IA 52242
BUILDING CHEMICAL LIBRARIES OF SPATIALLY COMPLEX TRICYCLIC MOLECULES USING A CASCADE REACTION
Angela Horst, Verónica M. Rivas and Horacio F. Olivo*
Division of Medicinal and Natural Products Chemistry, College of Pharmacy, The University of Iowa, Iowa City, IA 52242
DEVELOPMENT OF MOLECULAR BIOLOGY TOOL FOR MONITORING BIOREMEDIATION OF VINYL CHLORIDE IN GROUNDWATER
Yang Oh Jin and Timothy E. Mattes*
Civil and Environmental Engineering, College of Engineering, The University of Iowa, Iowa City, IA 52241
MITOCHONDRIAL TARGETED TRIPHENYLPHOSPHONIUM DERIVATIVES FOR TREATMENT OF METASTATIC MELANOMA
Kyle C. Kloepping, Douglas R. Spitz and Michael K. Schultz*
Department of Radiation Oncology (Free Radical and Radiation Biology Program), Roy J. and Lucille A. Carver College of Medicine, The University of Iowa, Iowa City, IA 52242
VC DEGRADATION BY METHANE-OXIDIZING AND ETHENE-OXIDIZING BACTERIA IN THE PRESENCE OF METHANE AND ETHENE MIXTURES
Meng Chen Lee and Timothy E. Mattes*
Department of Civil and Environmental Engineering, College of Engineering, The University of Iowa, Iowa City, IA 52242
BACTERIAL COMMUNITY STRUCTURES AND POLYCHLORINATED BIPHENYL BIODEGRADATION POTENTIAL IN SEDIMENTS FROM INDIANA HARBOR SHIPPING CANAL
Yi Liang, Joshua A. Livermore, Andres Martinez, Keri C. Hornbuckle and Timothy E. Mattes*
Department of Civil and Environmental Engineering, College of Engineering, The University of Iowa, Iowa City, IA 52242
KINETIC EVALUATION OF DUAL BINDING HUMAN ACETYLCHOLINESTERASE INHIBITORS
Alexander M. Lodge, Manza B. Atkinson, Elizabeth Elacqua, Daniel M. Quinn* and Leonard R. MacGillivray*
Department of Chemistry, College of Liberal Arts and Sciences, The University of Iowa, Iowa City, IA 52242
HIGH-THROUGHPUT SCREENING AND CHARACTERIZATION OF SMALL MOLECULE INHIBITORS OF THE Gα:RGS17 PROTEIN: PROTEIN INTERACTION FOR TREATMENT OF LUNG AND PROSTATE CANCERS
Duncan I. Mackie and David L. Roman*
Division of Medicinal and Natural Products Chemistry, College of Pharmacy, The University of Iowa, Iowa City, IA 52242
CHEMICAL TRAPPING OF AN INTERMEDIATE IN THE REACTION CATALYZED BY FLAVIN-DEPENDENT THYMIDYLATE SYNTHASE
Tatiana Mishanina, Eric M. Koehn, John A. Conrad, Bruce A. Palfey, Scott A. Lesley and Amnon Kohen*
Department of Chemistry, College of Liberal Arts and Sciences, The University of Iowa, Iowa City, IA 52242
NEW PATHWAY FOR CAFFEINE DEGRADATION IN PSEUDOMONAS sp. CBB1: NOVEL ENZYMES, GENES, AND METABOLITES
Sujit K. Mohanty, Chi Li Yu and Mani Subramanian*
Department of Chemical & Biochemical Engineering, College of Engineering, The University of Iowa, Iowa City, IA 52242 and Center for Biocatalysis & Bioprocessing, The University of Iowa Research Park, Coralville, IA 52241
MODIFICATION AND FUNCTIONAL INHIBITION OF REGULATOR OF G-PROTEIN SIGNALING 4 BY 4-HYDROXY-2-NONENAL
C. Aaron Monroy and David L. Roman*
Division of Medicinal and Natural Products Chemistry, College of Pharmacy, The University of Iowa, Iowa City, IA 52242
BEAUVARIA BASSIANA OXIDATIVE PERFORMANCE
Felipe Nicolau-Manterola¹, Richard Gonzalez¹, Tonya L. Peeples¹* and Horacio F. Olivo²*
¹Department of Chemical and Biochemical Engineering, College of Engineering, The University of Iowa, Iowa City, IA 52242
²Division of Medicinal and Natural Products Chemistry College of Pharmacy, The University of Iowa, Iowa City, IA 52242
PROBING THE PROPERTIES OF NANOPORES IN POROUS SILICA CHROMATOGRAPHY RESINS VIA SINGLE MOLECULE SPECTROSCOPY
Cicily Ronhovde and M. Lei Geng*
Department of Chemistry, College of Liberal Arts and Sciences, The University of Iowa, Iowa City, IA 52242
ROLE OF THE DNA-BINDING PROTEIN IsaB IN STAPHYLOCOCCUS AUREUS BIOFILMS
Carolyn B. Rosenthal and Alexander R. Horswill*
Department of Microbiology, Roy J. and Lucille A. Carver College of Medicine, The University of Iowa, Iowa City, IA 52242
USING KINETIC ISOTOPE EFFECTS TO ASSESS DYNAMIC MOTIONS OF THE SUBSTRATES IN ENZYMATIC H-TRANSFERS
Daniel Roston, Christopher M. Cheatum and Amnon Kohen*
Department of Chemistry, College of Liberal Arts and Sciences, The University of Iowa, Iowa City, IA 52242
ORGANIC NANOCRYSTALS OF SUPRAMOLECULAR MATERIALS
John R. G. Sander¹, Dejan-Krešimir Bucar¹, Rodger F. Henry², Jonas Baltrusaitis^1,3, Geoff G. Z. Zhang⁴* and Leonard R. MacGillivray¹*
¹Department of Chemistry, College of Liberal Arts and Sciences, The University of Iowa, Iowa City, IA 52242
²Structural Chemistry, Global Pharmaceutical R&D, Abbott Laboratories, Abbott Park, IL 60064
³Central Microscopy Research Facility, The University of Iowa, Iowa City, IA 52242
⁴Materials Science, Global Pharmaceutical R&D, Abbott Laboratories, Abbott Park, IL 60064
DIFFERENTIAL BINDING OF DNA WITH FLUOROQUINOLONES AFFECTS THE ABILITY OF THE FLUOROQUINOLONE TO KILL MICROORGANISMS
Heidi A. Schwanz and Robert J. Kerns.*
Division of Medicinal and Natural Products Chemistry, College of Pharmacy, The University of Iowa, Iowa City, IA 52242
HIGHLY EFFICIENT SYNTHESIS OF NOVEL OSW-1 ANALOGS
Aashay K. Shah and Zhendong Jin*
Division of Medicinal and Natural Products Chemistry, College of Pharmacy, The University of Iowa, Iowa City, IA 52242
NANOSTRUCTURED PHOTO CROSS-LINKED BIOPOLYMERS IN WOUND-HEALING AND DRUG DELIVERY APPLICATIONS
Kristan L. Sorenson1, C. Allan Guymon¹* and Aliasger K. Salem²*
¹Department of Chemical and Biochemical Engineering, College of Engineering, The University of Iowa, Iowa City, IA 52242
²Department of Pharmaceutics, College of Pharmacy, The University of Iowa, Iowa City, IA 52242
SUPRAMOLECULAR CATALYSIS IN THE ORGANIC SOLID STATE
Jelena Stojakovic and Leonard R. MacGillivray*
Department of Chemistry, College of Liberal Arts and Sciences, The University of Iowa, Iowa City, IA 52242
GENETIC CHARACTERIZATION OF CAFFEINE DEGRADATION via N-DEMETHYLATION BY PSEUDOMONAS PUTIDA CBB5
Ryan M. Summers, Michael Louie, Chi Li Yu, Kailin C. Louie and Mani Subramanian*
Department of Chemical and Biochemical Engineering, College of Engineering, The University of Iowa, Iowa City, IA 52242 and Center for Biocatalysis and Bioprocessing, The University of Iowa Research Park, Coralville, IA 52241
INVESTIGATING THE MECHANISM OF HEPATOCYTE INVASIAN BY MALARIA-CAUSING PLASMODIA BY DESIGNING AND SYNTHESIZING CHEMICAL PROBES
Tyrell R. Towle and Robert J. Kerns*
Division of Medicinal and Natural Products Chemistry, College of Pharmacy, The University of Iowa, Iowa City, IA 52242
INHIBITION AND PROTEIN MODIFICATION OF GAPDH BY THE ENDOGENOUS NEUROTOXIN-3,4-DIHYDROXYPHENYLACETALDEHYDE
Brigitte C. Vanle, Virginia Florang and Jonathan A. Doorn*
Division of Medicinal and Natural Products Chemistry, College of Pharmacy, The University of Iowa, Iowa City, IA 52242
THE ROLE OF ENZYME DYNAMICS IN THYMIDYLATE SYNTHASE CATALYZED REACTION: A COMBINED EXPERIMENTAL - THEORETICAL APPROACH
Zhen Wang¹, Vicent Moliner^2,3 and Amnon Kohen¹*
¹Department of Chemistry, College of Liberal Arts and Sciences, The University of Iowa, Iowa City, IA 52242
²Department de Química Física i Analítica, Universitat Jaume I, 12071 Castellón, Spain
³Institute of Applied Radiation Chemistry, Technical University of Lodz, 90-924 Lodz, Poland
NOVEL ANTIMUTANT C-7 ARYL FLUOROQUINOLONES
Benjamin H. Williamson, Heidi A. Schwanz and Robert J. Kerns*
Division of Medicinal and Natural Products Chemistry, College of Pharmacy, The University of Iowa, Iowa City, IA 52242
APPROACHES TO SYNTHESIS OF THE STELLETTINS
Veronica S. Wills and David F. Wiemer*
Department of Chemistry, College of Liberal Arts and Sciences, The University of Iowa, Iowa City, IA 52242
MODULAR AND EXPANDABLE DETECTION PLATFORM FOR CURRENT AND POTENTIAL FOOD TOXINS AND ADULTERANTS: SCREENING AND IDENTIFICATION OF MICROORGANISMS CONTAINING RICININE NITRILASE ACTIVITY
Chi Li Yu¹, Bhavita R. Bhatt¹, Michael Sadowsky², Lawrence P. Wackett² and Mani Subramanian¹*
¹Department of Chemical and Biochemical Engineering, College of Engineering, The University of Iowa, Iowa City, IA 52242 and Center for Biocatalysis and Bioprocessing, The University of Iowa Research Park, Coralville, IA 52241
²Department of Biochemistry, The University of Minnesota, St. Paul, MN 55108
CONTINUOUS NEAR INFRARED MONITOR FOR PICHIA PASTORIS BIOREACTORS
Elizabeth R. Gibson¹, Ed Koerperick¹, Kaylee Lanz¹, Jonathon T. Olesberg^1,2, Gary W. Small^1,2 and Mark A. Arnold^1,2
¹ASL Analytical, Inc., Coralville, IA 52241
²Optical Science and Technology Center and Department of Chemistry, College of Liberal Arts and Sciences, The University of Iowa, Iowa City, IA 52242
CONTINUOUS PROTEIN PURIFICATION USING SIMULATED MOVING BED: TAKING THE CHROMATOGRAPHY PLATFORM TO THE NEXT LEVEL
Anthony Grabski, Bruce Thalley, Alla Zilberman and Robert Mierendorf
Semba Biosciences, Inc., Madison, WI 53719

POSTER PREPARATION

(1)	The poster board has a 44" H x 68" W area for mounting the posters.
(2)	Lettering and illustrations on the poster pages must be large enough to be read by attendees from a distance of 3 feet or more.
(3)	Each poster must have a title, authors and affiliation section at the beginning. Material should be displayed in logical sequence (e.g., introduction, objectives, results, conclusion) and each sheet should be numbered.
(4)	Authors are responsible for mounting their own poster material on poster boards which will be provided at the conference. The Center will provide a reasonable supply of clear push pins. Posters should be removed immediately following the poster session and before dinner, since the poster boards are scheduled to be removed for use elsewhere.