Expanded Answers for Study Problems in: Rowland & Tozer's Clinical Pharmacokinetics: Concepts and Applications, 3rd edition

Chapter 3 - Intravenous Dose

Study Problems on Page 31

1. a) Correct. Recall that t_1/2 = 0.693/k. Thus, k = 0.693/ t_1/2, and k = 0.693/4hr = 0.173 hr^-1 .

d) Actually, to get the most accurate estimate of Ae^infinity, collection should occur for 7 half-lives, or 28 hours (5 half-lives, as the books suggests, is actually 20 hours, since the half-life is 4 hours).

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