Expanded Answers for Study Problems in: Rowland & Tozer's Clinical Pharmacokinetics: Concepts and Applications, 3rd edition
Chapter 5 - Therapeutic Response and Toxicity
Study Problems on Page 65
2. Effect often correlates better with plasma concentration that with dose because there is frequently a poor correlation between dose and plasma concentration as a result of varability in the disposition of the compound. This improved correlation between concentration and response occurs when plasma is in equilibrium with the biophase, the biological site of action.
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