Answer to Practice Problem #4 for Passage of Xenobiotics Across Biological Membranes Tutorial:

 

a)       increased

 

A reduced expression of p-glycoprotein would result in less p-glycoprotein in the intestinal cells through which drug must travel as it is absorbed. Since p-glycoprotein is an efflux protein, its presence results in a reduced oral bioavailability of drugs. Less p-glycoprotein would mean more drug gets through the intestinal cells and into the systemic circulation. Hence, oral bioavailability will be increased.

 

 

Last revised 06/04/04

 

ã 2004 -  Craig K. Svensson, Pharm.D., Ph.D.

 

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