The first step in determining the pharmacokinetic parameters desired is to determine AUC and AUMC. Since in this problem you are not given the concentration-time date, but rather the intercepts and rate constants, AUC and AUMC should be calculated from:

AUC = C₁/l ₁ + C₂/l ₂

AUMC = C₁/(l ₁)² + C₂/(l ₂)²

For this example, AUC = 96.4 mg^.hr/L and AUMC = 354 mg^.hr²/L

CL can be determined as

CL = D_iv ¸ AUC = 100 mg/96.4 mg^.hr/L = 1.04 L/hr

V_ss is given as

V_ss = (D_ivAUMC) ¸ (AUC)² = 3.8 L

MRT = V_ss ¸ CL = (3.8 L) ¸ (1.04 L/hr)

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