CURRENT TOPICS IN RADIATION AND CANCER BIOLOGY (77:548)

The University of Iowa

Fall 2010

11:30-12:30, Mondays

Room B180, Med Labs

Contact: apollina-goel@uiowa.edu Tel 319-384-4754


Presentations for Fall 2010:

Presenter: Josh Madsen
Paper:  Deng Y, Liu J, Han G, Lu SL, Wang SY, Malkoski S, Tan AC, Deng C, Wang XJ, Zhang Q. (2010) Redox-dependent Brca1 transcriptional regulation by an NADH-sensor CtBP1. Oncogene. [Epub ahead of print] PMID: 20818429

Presenter: Dr. Joshua Madsen
Paper: Di LJ, Fernandez AG, De Siervi A, Longo DL, Gardner K. (2010) Transcriptional regulation of BRCA1 expression by a metabolic switch. Nat Struct Mol Biol. 2010 Nov 21. [Epub ahead of print] PMID: 21102443

August 23, 2010
Presenter: Tony Cyr
Paper: Calo E, Quintero-Estades JA, Danielian PS, Nedelcu S, Berman SD, Lees JA. (2010) Rb regulates fate choice and lineage commitment in vivo. Nature. [Epub ahead of print]

August 30, 2010
Presenter: Dr. Prabhat Goswami
Paper: Poliseno L, Salmena L, Zhang J, Carver B, Haveman WJ, Pandolfi PP. (2010) A coding-independent function of gene and pseudogene mRNAs regulates tumor biology., Nature, 465:1033-1038

September 6, 2010
Presenter: Labor Day, No Journal Club

September 13, 2010
Presenter: Maneesh Kumar
Paper: Pedro P. Medin, Mona Nolde & Frank J. Slack. (2010) OncomiR addiction in an in vivo model of microRNA-21-induced pre-B-cell lymphoma. Nature [Epub ahead of print]

September 20, 2010
Presenter: Jordan Witmer
Paper: Tapryal N, Mukhopadhyay C, Mishra MK, Das D, Biswas S, Mukhopadhyay CK. (2010) Glutathione synthesis inhibitor butathione sulfoximine regulates ceruloplasmin by dual but opposite mechanism: Implication in hepatic iron overload. Free Radic Biol Med. 48(11):1492-500.

September 27, 2010
Presenter: Yueming Zhu
Paper: Kong X, Wang R, Xue Y, Liu X, Zhang H, Chen Y, Fang F, Chang Y. (2010) Sirtuin 3, a new target of PGC-1alpha, plays an important role in the suppression of ROS and mitochondrial biogenesis. PLoS One. 5(7):e11707

October 4, 2010
Presenter: Jaimee Eckers
Paper: Weinberg F, Hamanaka R, Wheaton WW, Weinberg S, Joseph J, Lopez M, Kalyanaraman B, Mutlu GM, Budinger GR, Chandel NS. (2010) Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity. Proc Natl Acad Sci U S A. 107(19):8788-93.

October 11, 2010
Presenter: Gaowei Mao
Paper: Hirschey MD, Shimazu T, Goetzman E, Jing E, Schwer B, Lombard DB, Grueter CA, Harris C, Biddinger S, Ilkayeva OR, Stevens RD, Li Y, Saha AK, Ruderman NB, Bain JR, Newgard CB, Farese RV Jr, Alt FW, Kahn CR, Verdin E. (2010) SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation. Nature. 464(7285):121-5.

October 18, 2010
Presenter: Dr. Frederick Domann
Paper: Conerly ML, Teves SS, Diolaiti D, Ulrich M, Eisenman RN, Henikoff S. (2010) Changes in H2A.Z occupancy and DNA methylation during B-cell lymphomagenesis.
Genome Res. 20(10):1383-90.

October 25, 2010
Presenter: Dr. Lauren Wegman
Paper: Hill VK, Underhill-Day N, Krex D, Robel K, Sangan CB, Summersgill HR, Morris M, Gentle D, Chalmers AD, Maher ER, and Latif F. (2010) Epigenetic inactivation of the RASSF10 candidate tumor suppressor gene is a frequent and an early event in gliomagenesis. Oncogene 1-12.

November 1, 2010
Presenter: Arya Sobhakumari
Paper: Zhu QS, Rosenblatt K, Huang KL, Lahat G, Brobey R, Bolshakov S, Nguyen T, Ding Z, Belousov R, Bill K, Luo X, Lazar A, Dicker A, Mills GB, Hung MC, Lev D. (2010) Vimentin is a novel AKT1 target mediating motility and invasion. Oncogene. [Epub ahead of print]

November 8, 2010
Presenter: Malvika Rawal
Paper: Salmeen A, Park BO, Meyer T. (2010) The NADPH oxidases NOX4 and DUOX2 regulate cell cycle entry via a p53-dependent pathway. Oncogene. 29(31):4473-84.

November 15, 2010
Presenter: Mindi TenNapel
Paper: Engel C, Versmold B, Wappenschmidt B, Simard J, Easton DF, Peock S, Cook M, Oliver C, et al. (2010) Association of the Variants CASP8 D302H and CASP10 V410I with Breast and Ovarian Cancer Risk in BRCA1 and BRCA2 Mutation Carriers. Cancer Epidemiol Biomarkers Prev. [Epub ahead of print]

November 22, 2010
Presenter: Thanksgiving Week, No Journal Club

November 29, 2010
Presenter: Jennifer Carr
Paper:  Taneja P, Maglic D, Kai F, Sugiyama T, Kendig RD, Frazier DP, Willingham MC, Inoue K. (2010) Critical Roles of DMP1 in Human Epidermal Growth Factor Receptor 2/neu-Arf-p53 Signaling and Breast Cancer Development. Cancer Res. 70(22):9084-94.

December 6, 2010
Presenter: Dr. Joshua Madsen
Paper: Deng Y, Liu J, Han G, Lu SL, Wang SY, Malkoski S, Tan AC, Deng C, Wang XJ, Zhang Q. (2010) Redox-dependent Brca1 transcriptional regulation by an NADH-sensor CtBP1. Oncogene. [Epub ahead of print] PMID: 20818429