CURRENT TOPICS IN RADIATION AND CANCER BIOLOGY (77:548)

The University of Iowa

Spring 2011

11:30-12:30, Mondays

Room B180, Med Labs

Contact: apollina-goel@uiowa.edu Tel 319-384-4754


Presentations for Spring 2011:

April 25, 2011
Presenter: Peter Scarbrough
Paper: Pinnix ZK, Miller LD, Wang W, D'Agostino R Jr, Kute T, Willingham MC, Hatcher H, Tesfay L, Sui G, Di X, Torti SV, Torti FM. (2010) Ferroportin and iron regulation in breast cancer progression and prognosis. Sci Transl Med. 2(43):43ra56. PMID: 20686179

May 2, 2011
Presenter: Dr. Joshua Madsen
Paper: Chao MP, Alizadeh AA, Tang C, Jan M, Weissman-Tsukamoto R, Zhao F, Park CY, Weissman IL, Majeti R. (2011) Therapeutic antibody targeting of CD47 eliminates human acute lymphoblastic leukemia. Cancer Res. 71(4):1374-84. PMID: 21177380

January 24, 2011
Presenter: Dr. Melissa Fath
Paper: Mandal PK, Seiler A, Perisic T, Kölle P, Banjac Canak A, Förster H, Weiss N, Kremmer E, Lieberman MW, Bannai S, Kuhlencordt P, Sato H, Bornkamm GW, Conrad M. (2010) System x(c)- and thioredoxin reductase 1 cooperatively rescue glutathione deficiency. J Biol Chem. 285(29):22244-53. PMID: 20463017

January 31, 2011
Presenter: Jaimee Eckers
Paper: Park HJ, Carr JR, Wang Z, Nogueira V, Hay N, Tyner AL, Lau LF, Costa RH, Raychaudhuri P. (2009) FoxM1, a critical regulator of oxidative stress during oncogenesis. EMBO J. 28(19):2908-18. PMID: 19696738

February 7, 2011
Presenter: Canceled

February 14, 2011
Presenter: Trenton Place
Paper: Doedens et al. (2010) Macrophage expression of hypoxia-inducible factor-1 alpha suppresses T-cell function and promotes tumor progression. Cancer Res. 2010. PMID: 20841473

February 21, 2011
Presenter: Dr. Prabhat Goswami
Paper: Gilbert LA, Hemann MT. (2010) DNA damage-mediated induction of a chemoresistant niche. Cell. 143(3):355-66. PMID: 21029859

February 28, 2011
Presenter: Maneesh Kumar
Paper: Lim PK, Bliss SA, Patel SA, Taborga M, Dave MA, Gregory LA, Greco SJ, Bryan M, Patel PS, Rameshwar P. (2011) Gap Junction-Mediated Import of MicroRNA from Bone Marrow Stromal Cells Can Elicit Cell Cycle Quiescence in Breast Cancer Cells. Cancer Res. [Epub ahead of print] PMID: 21343399

March 7, 2011
Presenter: C. Michael Knudson
Paper: Guo JY, Chen HY, Mathew R, Fan J, Strohecker AM, Karsli-Uzunbas G, Kamphorst JJ, Chen G, Lemmons JM, Karantza V, Coller HA, Dipaola RS, Gelinas C, Rabinowitz JD, White E. (2011) Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis. Genes Dev. [Epub ahead of print] PMID: 21317241

March 14, 2011
Presenter: No Presentation Spring Break

March 21, 2011
Presenter: Dr. Frederick Domann
Paper:  Tanwar PS, Zhang L, Roberts DJ, Teixeira JM. (2011) Stromal Deletion of the APC Tumor Suppressor in Mice Triggers Development of Endometrial Cancer. Cancer Res. 71(5):1584-96. PMID: 21363919

March 28, 2011
Presenter: William D. Bennett
Paper: Stephens, PJ, et al. (2011) Massive Genomic Rearrangement Acquired in a Single Catastrophic Event during Cancer Development. Cell, 44:27-40.
PMID: 21215367

April 4, 2011
Presenter: Dr. James Jacobus
Paper:  Indran IR, Hande MP, Pervaiz S. (2011) hTERT overexpression alleviates intracellular ROS production, improves mitochondrial function, and inhibits ROS-mediated apoptosis in cancer cells. Cancer Res. 71(1):266-76. PMID: 21071633 

April 10, 2011
Presenter: Dr. Lauren Wegman
Talk: Beatty GL, Chiorean EG, Fishman MP, Saboury B, Teitelbaum UR, Sun W, Huhn RD, Song W, Li D, Sharp LL, Torigian DA, O'Dwyer PJ, Vonderheide RH. (2011) CD40 agonists alter tumor stroma and show efficacy against pancreatic carcinoma in mice and humans. Science. 331(6024):1612-6. PMID: 21436454

April 18, 2011
Presenter: Tony Cyr
Paper: Cortazar D, Kunz C, Selfridge J, Lettier T, Saito Y, MacDougall E, Wirz A, et al. (2011) Embryonic lethal phenotype reveals a function of TDG in maintaining epigenetic stability. Nature, in press. PMID: 21278727