CURRENT TOPICS IN RADIATION AND CANCER BIOLOGY (77:548)

The University of Iowa

Fall 2012

11:30-12:30, Every other Monday

Room B180, Med Labs

Contact: apollina-goel@uiowa.edu Tel 319-384-4754


Presentations for Fall 2012:

 August 20, 2012
Presenter: Dr. Frederick Domann
Paper:  Jain M, Nilsson R, Sharma S, Madhusudhan N, Kitami T, Souza AL, Kafri R, Kirschner MW, Clish CB, Mootha VK. Metabolite profiling identifies a key role for glycine in rapid cancer cell proliferation. Science. 2012 May 25; 336(6084):1040-4. PMID: 22628656

September 3, 2012
Presenter:  Labor Day, no journal club

Sept 17, 2012
Presenter:  Jeffrey He
Paper:  Misale S, Yaeger R, Hobor S, Scala E, Janakiraman M, Liska D, Valtorta E, Schiavo R, Buscarino M, Siravegna G, Bencardino K, Cercek A, Chen CT, Veronese S, Zanon C, Sartore-Bianchi A, Gambacorta M, Gallicchio M, Vakiani E, Boscaro V, Medico E, Weiser M, Siena S, Di Nicolantonio F, Solit D, Bardelli A. Emergence of KRAS mutations and acquired resistance to anti-EGFR therapy in colorectal cancer. Nature. 2012 Jun 28;486(7404):532-6. PMID:22722830

October 1, 2012
Presenter:  Wusheng Xiao
Paper:  Sun Y, Campisi J, Higano C, Beer TM, Porter P, Coleman I, True L, Nelson PS. Treatment-induced damage to the tumor microenvironment promotes prostate cancer therapy resistance through WNT16B. Nat Med. 2012 Aug 5. doi: 10.1038/nm.2890. [Epub ahead of print]  PMID:22863786

October 15, 2012
Presenter:  Kelley Salem
Paper:  Guido C, Whitaker-Menezes D, Capparelli C, Balliet R, Lin Z, Pestell RG, Howell A, Aquila S, Andò S, Martinez-Outschoorn U, Sotgia F, Lisanti MP. Metabolic reprogramming of cancer-associated fibroblasts by TGF-β drives tumor growth: Connecting TGF-β signaling with "Warburg-like" cancer metabolism and L-lactate production. Cell Cycle. 2012 Aug 15;11(16):3019-35. Epub 2012 Aug 9.  PMID:22874531
[DOI Article]

October 29, 2012
Presenter:  James Jacobus
Paper:  Lu W, Hu Y, Chen G, Chen Z, Zhang H, Wang F, Feng L, Pelicano H, Wang H, Keating MJ, Liu J, McKeehan W, Wang H, Luo Y, Huang P. Novel role of NOX in supporting aerobic glycolysis in cancer cells with mitochondrial dysfunction and as a potential target for cancer therapy. PLoS Biol. 2012; 10(5):e1001326. Epub 2012 May 8 PMID: 22589701  PMCID:PMC3348157
[DOI Article]

November 12, 2012
Presenter:  Philip Spanheimer
Paper:  Wang C, Mayer JA, Mazumdar A, Brown PH. The rearranged during transfection/papillary thyroid carcinoma tyrosine kinase is an estrogen-dependent gene required for the growth of estrogen receptor positive breast cancer cells. Breast Cancer Res Treat. 2012 Jun; 133(2):487-500. Epub 2011 Sep 24. 
PMID: 21947652  PMCID:PMC3424514
[DOI Article]

November 26, 2012
Presenter:  Elise Fletcher
Paper:  Vo TT, Ryan J, Carrasco R, Neuberg D, Rossi DJ, Stone RM, Deangelo DJ, Frattini MG, Letai A. Relative Mitochondrial Priming of Myeloblasts and Normal HSCs Determines Chemotherapeutic Success in AML. Cell. 2012 Oct 12;151(2):344-55. doi: 10.1016/j.cell.2012.08.038.  PMID:23063124
[DOI Article]

December 10, 2012
Presenter:  Jennifer Hrabe
Paper: Zhou Y, Tozzi F, Chen J, Fan F, Xia L, Wang J, Gao G, Zhang A, Xia X, Brasher H, Widger W, Ellis LM, Weihua Z. Intracellular ATP levels are a pivotal determinant of chemoresistance in colon cancer cells. Cancer Res. 2012 Jan 1;72(1):304-14. Epub 2011 Nov 14.  PMID: 22084398 
[DOI Article]