CURRENT TOPICS IN RADIATION AND CANCER BIOLOGY (77:548)

The University of Iowa

Season 2014

11:30-12:30, Mondays

Room B180, Med Labs

Contact: apollina-goel@uiowa.edu Tel 319-384-4754


Presentations for Season 2014:

April 21, 2014
Presenter: Dr. Douglas R. Spitz
Paper: Yang WS1, Sriramaratnam R2, Welsch ME2, Shimada K1, Skouta R1, Viswanathan VS3, Cheah JH4, Clemons PA4, Shamji AF4, Clish CB4, Brown LM5, Girotti AW6, Cornish VW2, Schreiber SL4, Stockwell BR7. Regulation of Ferroptotic Cancer Cell Death by GPX4. Cell. 2014 Jan 16;156(1-2):317-31. PMID:24439385.
[DOI Link, http://dx.doi.org/doi:10.1016/j.cell.2013.12.010]

May 5, 2014
Presenter: Kyle Kloepping
Paper: Gusarov I, Gautier L, Smolentseva O, Shamovsky I, Eremina S, Mironov A, Nudler E. Bacterial nitric oxide extends the lifespan of C. elegans. Cell. 2013 Feb 14;152(4):818-30. PMID: 23415229
[DOI Link, http://dx.doi.org/10.1016/j.cell.2012.12.043]

January 20, 2014
Presenter: No Journal Club, Office is closed

February 3, 2014
Presenter: John Lafin
Paper: Fu Y, Yang G, Zhu F, Peng C, Li W, Li H, Kim HG, Bode AM, Dong Z, Dong Z. Antioxidants decrease the apoptotic effect of 5-Fu in colon cancer by regulating Src-dependent caspase-7 phosphorylation. Cell Death Dis. 2014 Jan 9;5:e983. PMID:24407236.
[DOI Link,
ttp://www.nature.com/cddis/journal/v5/n1/full/cddis2013509a.html

February 17, 2014
Presenter: Joshua Schoenfeld
Paper: Ma Y, Chapman J, Levine M, Polireddy K, Drisko J, and Chen Q. (2014) High-Dose Parenteral Ascorbate Enhanced Chemosensitivity of Ovarian Cancer and Reduced Toxicity of Chemotherapy. Sci. Transl. Med., 6(222):222ra18.
[DOI Link, http://dx.doi.org/doi:10.1126/scitranslmed.3007154]

March 3, 2014
Presenter: Jyungmean Son
Paper: Yi W, Clark PM, Mason DE, Keenan MC, Hill C, Goddard WA 3rd, Peters EC, Driggers EM, Hsieh-Wilson LC. Phosphofructokinase 1 glycosylation regulates cell growth and metabolism. Science. 2012 Aug 24;337(6097):975-80. PMID:22923583 PMCID:PMC3534962. [DOI Link, http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3534962/].

March 17, 2014 -- SPRING BREAK, No journal club

March 24, 2014
Presenter: Amanda Kalen
Paper: Javvadi P1, Segan AT, Tuttle SW, Koumenis C. The chemopreventive agent curcumin is a potent radiosensitizer of human cervical tumor cells via increased reactive oxygen species production and overactivation of the mitogen-activated protein kinase pathway. Mol Pharmacol. 2008 May;73(5):1491-501. PMID: 18252805 PMCID: PMC3400533.
[DOI Link, http://dx.doi.org/10.1124%2Fmol.107.043554]

April 7, 2014
Presenter: Madelyn Espinosa
Paper: Brockmann M, Poon E, Berry T, Carstensen A, Deubzer HE, Rycak L, Jamin Y, Thway K, Robinson SP, Roels F, Witt O, Fischer M, Chesler L, Eilers M. Small molecule inhibitors of aurora-a induce proteasomal degradation of N-myc in childhood neuroblastoma. Cancer Cell. 2013 Jul 8;24(1):75-89. PMID: 23792191
[DOI Link, http://dx.doi.org/doi:10.1016/j.ccr.2013.05.005].