Grants Recently Awarded
Grants Recently Awarded:
April,2008: Dr. Lai Tee “Melissa” Teoh was awarded a $85,000 two year Postdoctoral Fellowship from the American Heart Association for her grant titled: “A Role for Homocysteine in Regulating Extracellular Superoxide Dismutase Function in Cardiovascular Diseases”. Dr. Teoh’s study how Hyperhomocysteinemia (HHcy), a condition with increased circulating levels of homocysteine (Hcy), is an independent risk factor for atherosclerotic cardiovascular diseases. It has been suggested that Hcy may induce vascular dysfunction through oxidative damage by preventing the binding of extracellular superoxide dismutase (EcSOD) to endothelial cell surfaces. The overall hypothesis of this proposal is that Hcy-mediated pathogenesis of cardiovascular diseases involves an impairment of EcSOD function.
March, 2008: Dr. Garry Buettner has received a NIH R01 award for his grant titled: “Quantitative Redox Biology”. The objective is to quantify on an absolute basis the level of free radicals, related oxidants and antioxidants (small-molecule and enzymes) in cells and tissues; to establish a database of this information that can be used as input to model the chemical processes in cells and tissues that determine the intracellular redox environment; and make this information freely available to the public.
March, 2008: Dr. Joseph Cullen has received a Veteran’s Administration Merit Review Award for his grant titled: “Therapeutic Modulation of Superoxide in Pancreatic Cancer”.
The goal of this project is to determine if plasma membrane-generated superoxide can be modulated for therapeutic purposes in pancreatic cancer.
February, 2008: Graduate Student, Adam Case, received a $99,900 three year Predoctoral Prostate Cancer Training Award from the Department of Defense for his grant titled: “Epigenetic Control of Prolyl and Asparaginyl Hydroxylases in Prostate Cancer”. The research will focus upon the phenomenon commonly associated with prostate cancer known as hypoxia induced gene regulation. The understanding of this pathway is essential in the full elucidation of how prostate cancer is able to initiate, propagate, and metastasize.
February, 2008: Dr. Apollina Goel has received a $50,000 grant from the Holden Comprehensive Cancer Center to design and develop unique approaches that can improve the therapeutic efficacy of radiotherapy enabling a higher complete remission (CR) rate and cure of B cell NHL. The effectiveness of radioimmunotherapy + CpG, the anti-lymphoma activity of everolimus (RAD001), and the in vitro radiosensitization by mTOR inhibitors when taken together provide clear support for the overall hypothesis of this project that targeting PI3K/Akt/mTOR kinase and/or the ubiquitin proteasome pathway (26S proteasome) using cytotoxic drugs will selectively sensitize lymphoma cells to radiation and improve the therapeutic index of lymphoma-targeted radiotherapy without or with CpG ODN. The studies will provide basis to design novel radiotherapy based Phase I/II clinical trials that can have significant impact of curability of B cell NHL.
January, 2008: Dr. Apollina Goel has received a $185,227 two year grant from Multiple Myeloma Research Foundation to develop novel non-myeloablative radionuclide-based salvage regimens that can collaborate clinical testing in patients who are not candidates for stem cell transplantation or who are relapsing after conventional myeloma therapy.
December, 2007: Dr. Sujatha Venkataraman received a $40,000 award from Holden Comprehensive Cancer Center.
November, 2007: Dr. Prabhat Goswami received private funding for five years to study “Free Radicals and Quiescent Cell and Molecular Biology”. The significance of this research is the novel idea that age-associated changes in cellular redox environment could have adverse effects on quiescent fibroblasts’ proliferation and motility, which could significantly impact upon the wound healing process. If the stated hypothesis is proven to be true, preventive and therapy-related clinical applications of antioxidants (antioxidant enzymes and small molecular weight antioxidants) could significantly enhance the wound healing process and minimize scarring.
July, 2007: Maneesh Kumar has received the Doris Duke Fellowship Award for Research.
May, 2007: Dr. Frederick Domann received a one year $73,750 EHSRC pilot project grant. The goal of this project is to investigate the role of all three polymorphisms in the EPX gene and search for statistically significant associations between the presence of particular haplotypes and the risk of asthma.
April, 2007: Dr. Larry Oberley has received a $1.2 million five year R01 award from NIH for his grant titled: “Molecular Species Responsible for Tumor Suppressive Effect of MnSOD”. The research is about how the mitochondrial antioxidant enzyme manganese-containing superoxide dismutase (MnSOD) has been shown to be a tumor suppressor in a wide variety of different cancer cell types. The mechanism of tumor suppression by MnSOD will be examined along with which reactive oxygen or nitrogen species is involved.
Disha Dayal, Best poster award for SFRR Meeting in India
Adam Case, position on Molecular and Cellular Biology Training Grant and travel award for the Molecular and Cellular Biology poster session.
Disha Dayal, Young Investigators Award, SFRBM and best poster at the College of Medicine research week at the University of Iowa.
Ehab Sarsour, International Congress for Radiation Research, San Francisco.
Ehab Sarsour, Society of Free Radical Biology & Medicine annual meeting, Washington DC.
Yueming Zhu, Travel Award for the CS-SOT annul meeting
Oksana Zagorodna, Scholarly Presentation Award, University of Iowa and
Graduate Student Senate Travel Funds Award, University of Iowa.
Disha Dayal, Young Investigators Award, SFRBM, GSS travel award, UISG travel award, and Women in Science and Engineering travel award.
Hualei Li, UISG travel award.
Sarita Menon, Travel Award and Oral Presentation at the 12th Annual Meeting of Society for Free Radical Biology and Medicine.
Disha Dayal, UISG travel award.