Dr. Prabhat Goswami - Professor
4210 Medical Education and Biomedical Research Facility (MERF)
The University of Iowa
Iowa City, IA 52242-1181
Tel : (319) 384-4666
Fax: (319) 335-8039
Dr. Goswami's laboratory is pursuing a mechanistic understanding of the role intracellular redox-state plays in regulating the mammalian cell cycle, and the establishment of a link between reactive oxygen species (ROS)-signaling and other aspects of intracellular signaling network during normal cell aging and cancer cell therapy response.
Research efforts are focused on understanding the possible role of mitochondria generated ROS-signaling pathways regulating (a) normal fibroblast aging; (b) fibroblast aging on cancer cell proliferation and therapy response; and (c) cancer cell quiescence and radiation therapy response. Molecular and pharmaceutical methods are used to determine a mechanistic role of antioxidant and cell cycle genes regulating fibroblast aging and cancer cell therapy response.
Additional research efforts include investigating the role of oxidative stress regulating cellular response to polychlorinated biphenyl (environmental pollutant) and antioxidants mitigating these adverse effects.
The knowledge gained from these research projects may provide novel insights into the redox-regulation of the mammalian cell cycle both in physiological as well as pathological states. This knowledge may allow us to develop antioxidant-based preventive and therapy protocols to promote healthy-aging and delay the onset of age-associated proliferative diseases.
Example Publications | Full CV
Ehab H. Sarsour, Amanda L. Kalen, and Prabhat C. Goswami. Manganese superoxide dismutase regulates a redox cycle within the cell cycle. Antioxidants & Redox Signaling 2013, In press; PMID: 23590434. http:/dx.doi.org/doi:10.1089/ars.2013.5303
Jaimee Eckers, Amanda L. Kalen, Ehab H. Sarsour, Wusheng Xiao, and Prabhat C. Goswami. Selenoprotein P inhibits radiation-induced late reactive oxygen species accumulation and normal cell injury. International Journal of Radiation, Oncology, Biology, Physics 2013, 87(3):619-625; PMID: 24074935; PMC3787541. http:/dx.doi.org/doi:10.1016/j.ijrobp.2013.06.2063.
Wusheng Xiao, Yueming Zhu, Ehab H. Sarsour, Amanda L. Kalen, Nukhet Aykin-Burns, Douglas R. Spitz, and Prabhat C. Goswami. Selenoprotein P regulates1-(4-chlorophenyl)-benzo-2,5-quinone induced oxidative stress and toxicity in human keratinocytes. Free Radical Biology and Medicine 2013, 65:70-77; PMID: 23770201; NIHMS 492238 http://dx.doi.org/10.1016/j.freeradbiomed.2013.06.010.
Maneesh G. Kumar, Neil M. Patel, Adam M. Nicholson, Amanda L. Kalen, Ehab H. Sarsour, Prabhat C. Goswami. Reactive oxygen species mediate microRNA-302 regulation of AT-Rich Interacting Domain 4a and C-C motif Ligand 5 expression during transitions between quiescence and proliferation. Free Radical Biology and Medicine 2012, 53:974-982; PMID: 22732186; PMC3418417; http://dx.doi.org/10.1016/j.freeradbiomed.2012.06.019
Ehab H. Sarsour, Amanda L. Kalen, Zhen Xiao, Timothy D. Veenstra, Leena Chaudhuri, Sujatha Venkataraman, Philip Reigan, Garry R. Buettner, and Prabhat C. Goswami. Manganese superoxide dismutase activity regulates a metabolic switch during the mammalian cell cycle. Cancer Research 2012, 72:3807-3816; PMID: 22710435; PMC3429130 http://cancerres.aacrjournals.org/cgi/content/abstract/0008-5472.CAN-11-1063
Leena Chaudhuri, Adam M. Nicholson, Amanda L. Kalen, and Prabhat C. Goswami. Preferential selection of MnSOD transcripts in proliferating normal and cancer cells. Oncogene 2012, 31(10):1207-1216; PMID: 21804600; PMC 3208126; http://dx.doi.org/doi:10.1038/onc.2011.325
Sarsour EH, Kumar M, Goswami M, Kalen AL, Buettner GR, and Goswami PC. MnSOD activity regulates hydroxytyrosol-induced extension of chronological life span. Age 2012, 34(1):95-109. PMID 21384152; PMC3260369; http://dx.doi.org/doi:10.1007/s11357-011-9223-7
Honors, Awards, and Organizations
- 1974-1976 National Merit Scholarship, India
- 1974 Awarded the Nehru Memorial prize for academic excellence; B.Sc. (Chem. Honors)
- 2002-2007 Radiological Society of North America (RSNA) Research & Education Foundation, scientific reviewer
- 2004-2007 Susan G. Komen Breast Cancer Foundation, scientific reviewer
- 2005-present Adhoc scientific reviewer for NIH, DOD, DOE, NASA
- 2013 NIH CE Study Section Member
- 1983 PhD, Chemistry, Gauhati University, India
- 1976 MS, Chemistry, Gauhati University, India
- 1974 BS with honors, Chemistry, St. Anthony's College, Shillong, India
- 1978-1983 Pre-doctoral Fellow, Regional Research Laboratory, Jorhat, India
- 1986-1988 Post-doctoral Fellow, Department of Microbiology, University of Miami, Miami, Florida