Dr. Prabhat Goswami-Associate Professor

 

 

 

 

 

 

Research Interests

Dr. Goswami's laboratory is pursuing mechanistic understanding of the role intracellular redox-state plays in regulating the mammalian cell cycle, and the establishment of a link between reactive oxygen species (ROS)-signaling and other aspects of intracellular signaling networks during normal cellular proliferation and in response to oxidative stress.

Research efforts are concentrated in identifying the molecular mechanisms regulating cellular redox environment during the cell cycle and redox-sensitive expression of cell cycle regulatory proteins including cyclins, CDKs, CKIs, CDC25, and Rb. 

Research efforts are also ongoing identifying the cellular effects of environmental pollutants, polychlorinated biphenyls (PCBs). The possible role of oxidative stress in PCB-induced DNA damage, perturbation in cellular proliferation, and cell death is currently being investigated.

Additional research interest includes investigating the possible role of intracellular redox environment in cell proliferation and migration during wound healing, radiation-induced cell cycle checkpoint pathways, and post-transcriptional gene regulation.

The knowledge gained from these research projects may provide novel insights into the redox-regulation of the mammalian cell cycle both in physiological as well as pathological states. This knowledge may allow us to devise better treatment protocols based on redox control of the cell cycle.

Example Publications

Sarsour EH, Kalen AL, Venkataraman S, Larry W. Oberley, and Goswami PC. Manganese superoxide dismutase activity regulates transitions between quiescent and proliferative growth.  Aging Cell (2008, in press).

Marlan R. Hansen, J. Jason Clark, Bruce J. Grantz, and Goswami PC. Effects of Erb2 signaling on the response of vestibular schwannoma cells to g-irradiation. Laryngoscope  118, 2008 (in press).

Menon SG, Sarsour EH, Kalen AL, Venkataraman S, Oberley LW, and Goswami PC. Superoxide signaling mediates N-acetyl-L-cysteine induced G1 arrest: Regulatory role of manganese superoxide dismutase and cyclin D1.  Cancer Research, 2007, 67:6392-6399.

Menon SG, and Goswami PC. A redox cycle within the cell cycle: Ring in the old with the new. Oncogene 2007, 26:1101-1109.

Bock JM, Menon SG, Sinclair LL, Bedford NS, Goswami PC, Domann RE, and Trask DK.  Celecoxib toxicity is cell cycle phase specific.  Cancer Research, 2007, 67:3801-3808.

Kalen, AL, Sarsour EH, Venkataraman S, and Goswami PC. Mn-superoxide dismutase over expression enhances G2-accumulation and radioresistance in human oral squamous carcinoma cells. Antioxidants & Redox Signaling, 8:1273-1281, 2006.

Sarsour EH, Agarwal M, Pandita TK, Oberley LW, and Goswami PC. Manganese superoxide dismutase protects the proliferative capacity of confluent normal human fibroblasts. J. Biol. Chem. 280:18033-18041, 2005.

Menon SG, Sarsour EH, Spitz DR, Higashikubo R, Sturm M, Zhang H and Goswami PC. Redox regulation of the G1 to S transition in the mouse embryo fibroblast cell cycle. Cancer Research63, 2109-2117, 2003.

Education

• 1983 PhD, Chemistry, Gauhati University, India
• 1976 MS, Chemistry, Gauhati University, India
• 1974 BS with honors, Chemistry, St. Anthony's College, Shillong, India

Post-Graduate Education

• 1978-1983 Pre-doctoral Fellow, Regional Research Laboratory, Jorhat, India
• 1986-1988 Post-doctoral Fellow, Department of Microbiology, University of Miami, Miami, Florida