Dr. Prabhat Goswami - Professor
4210 Medical Education and Biomedical Research Facility (MERF)
The University of Iowa
Iowa City, IA 52242-1181
Tel : (319) 384-4666
Fax: (319) 335-8039
Dr. Goswami's laboratory is pursuing mechanistic understanding of the role intracellular redox-state plays in regulating the mammalian cell cycle, and the establishment of a link between reactive oxygen species (ROS)-signaling and other aspects of intracellular signaling networks.
Research efforts are focused in understanding the possible role of mitochondrial generated ROS-signaling pathways regulating (a) chronological lifespan of normal fibroblasts; and (b) the effect of chronological lifespan of fibroblasts on cancer cell proliferation. Molecular methods and small molecular weight antioxidants are used to study antioxidants and cell cycle gene expression regulating chronological lifespan and cancer cell proliferation.
Additional research efforts include studying the (a) role of ROS-signaling in polychlorinated biphenyl (environmental pollutant) induced perturbation in cellular proliferation and cytotoxicity; and (b) molecular mechanisms regulating late ROS-accumulation, and cellular response to ionizing radiation.
The knowledge gained from these research projects may provide novel insights into the redox-regulation of the mammalian cell cycle both in physiological as well as pathological states. This knowledge may allow us to develop antioxidant-based preventive and therapy protocols to promote healthy-aging and delay the onset of age-associated proliferative diseases.
Example Publications | Full CV
Leena Chaudhuri, Adam M. Nicholson, Amanda L. Kalen, and Prabhat C. Goswami. Preferential selection of MnSOD transcripts in proliferating normal and cancer cells. Oncogene (2011, in press).
Sarsour EH, Kumar M, Goswami M, Kalen AL, Buettner GR, and Goswami PC. MnSOD activity regulates hydroxytyrosol-induced extension of chronological life span. Age, 2011, DOI 10.1007/s11357-011-9223-7.
Venkatesha VA., Kalen AL, Sarsour EH, and Goswami PC. PCB-153 exposure coordinates cell cycle progression and cellular metabolism in human mammary epithelial cells. Toxicology Letters, 2010, 196(2):110-116. PMC2891036.
Chaudhuri L, Sarsour EH, Kalen AL, Aykin-Burns N, Spitz DR, and Goswami PC. Polychlorinated biphenyl-induced ROS-signaling delays the entry of quiescent human breast epithelial cells into the proliferative cycle. Free Radical Biology & Medicine, 2010, 49(1):40-49. PMC2875331.
Sarsour EH, Kumar MG, Chaudhuri L, Kalen AL, and Goswami PC. Redox control of cell cycle in health and disease. Antioxidants & Redox Signaling, 2009, 11(12):2985-3011; PMC:2783918.
Du C, Gao Z, Venkatesha VA., Kalen AL, Chaudhuri L, Spitz DR, Cullen JJ, Oberley LW, and Goswami PC. Mitochondrial ROS and radiation induced transformation in mouse embryonic fibroblasts. Cancer Biology & Therapy2009, 8(20):1962-1971; PMC2795790 [DOI Link]
Sarsour EH, Kalen A, Goswami M and Goswami PC. MnSOD activity protects mitochondrial morphology of quiescent fibroblasts from age-associated abnormalities. Mitochondrion 2010, 10(4):342-9. PMC2874624 [DOI Link].
Leena Chaudhuri, Adam M. Nicholson, Amanda L. Kalen, and Prabhat C. Goswami. Preferential selection of MnSOD transcripts in proliferating normal and cancer cells. Oncogene (2011) Aug 1. DOI: 10.1038/onc.2011.325. [Epub ahead of print]; PMID: 21804600
- 1983 PhD, Chemistry, Gauhati University, India
- 1976 MS, Chemistry, Gauhati University, India
- 1974 BS with honors, Chemistry, St. Anthony's College, Shillong, India
- 1978-1983 Pre-doctoral Fellow, Regional Research Laboratory, Jorhat, India
- 1986-1988 Post-doctoral Fellow, Department of Microbiology, University of Miami, Miami, Florida