Melissa Fath, PhD

Department of Radiation Oncology
Free Radical and Radiation Biology
B180 Med Labs
The University of Iowa
Iowa City, IA 52242-1101, USA

Work: (319) 335-8025
Fax: (319) 335-8039









Spitz Lab


Fath, M.A., Wu, X., Hileman, R.E., Linhardt, R.J., Kashem, M.A., Nelson, R.M., Wright, C.D., and Abraham, W.M. Interaction of secretory leukocyte protease inhibitor with heparin inhibits proteases involved in asthma. Journal of Biological Chemistry, 1998; 273: 13563-9.

Fath, M., VanderNoot, V., Kilpelainen, I., Kinnunen, T., Rauvala, H., and Linhardt, R.J. Interaction of soluble and surface-bond heparin binding growth-associated molecule with heparin. FEBS Letters, 1999; 454:105-8.

Kilpelainen, I. Kaksonen, M., Avikainen, H., Fath, M., Linhardt, R.J., Raulo, E., and Rauvala, H. Heparin-binding growth-associated molecule contains two heparin-binding beta-seet domains that are homologous to the thrombospondin type 1 repeat. Journal of Biological chemistry, 2000; 275, 13564-70.

Zhang, F., Fath, M.A., Marks, R. and Linhardt, R.J. A Highly stable covalent conjugated heparin biochip for heparin-protein interaction studies. Analytical Biochemistry, 2002; 304, 271-273.

Nishimura D.Y., Fath M., Mullins R.F., Searby C., Andrews M., Davis R., Andorf J.L., Mykytyn K., Swiderski R.E., Yang B., Carmi R., Stone E.M., Sheffield V.C. Bbs2-null mice have neurosensory deficits, a defect in social dominance, and retinopathy associated with mislocalization of rhodopsin. Proceedings of the National Academy of Science U S A, 2004; 101(47):16588-93.

Fath M., Nishimura D.Y., Mullins R.F., Searby C., Andrews M., Wen, J., Davis R., Kamal, Yang B, Stone EM, Sheffield VC. MKKS-null mice have a phenotype resembling Bardet-Biedl Syndrome. Human Molecular Genetics, 2005; 14(9):1109-18

Simons A.L., Fath M.A., Mattson D.M., Smith B.J., Walsh S.A., Graham M.M., Hichwa R.D., Buatti J.M., Dornfeld K., Spitz D.R. Enhanced Response of Human Head and Neck Cancer Xenograph Tumors to Cisplatin Combined With 2-Deoxy-d-Glucose Correlates With Increased (18)F-FDG Uptake as Determined by PET Imaging. International Journal of Radiation Oncology, Biology, and Physics. 2007; 69(4):1222-30

Rahmouni K., Fath M.A., Seo S., Thedens D.R., Berry C.J., Weiss R., Nishimura D.Y., Sheffield V.C. Leptin resistance contributes to obesity and hypertension in mouse models of Bardet-Biedl syndrome. Journal of Clinical Investigation. 2008; 118(3).

Fath, M.A., Diers, A.R., Aykin-Burns, N., Simons, A.L., Hua, L., Spitz, D.R. Mitochondrial electron transport chain blockers enhance 2-deoxy-D-glucose induced oxidative stress and cell killing in human colon carcinoma cells. Cancer Biology and Therapy. 2009; 8(13).

Simons AL, Parsons AD, Foster KA, Orcutt KP, Fath MA, and Spitz DR. Inhibition of Glutathione and Thioredoxin Metabolism Enhances Sensitivity to Perifosine in Head and Neck Cancer Cells. Journal of Oncology. 2009; 2:1-10.