The Spitz Laboratory is involved with the study of free radicals and oxidative stress in biology and medicine. Ongoing projects include the study of phenotypic changes associated with oxidative stress-resistant mammalian cell lines, oxidative stress in toxicology, molecular mechanisms of resistance to oxidative stress, the role of mitochondrial derived ROS in cancer biology, oxidative stress and radiation injury, redox regulation of signal transduction and gene expression as well as metabolic oxidative stress associated with glucose deprivation-induced cytotoxicity in human tumor cells. The long term goal is to use a basic science understanding of mechanisms associated with free radical toxicology to elucidate novel methods for manipulating clinically significant outcomes in areas of medicine relevant to cancer biology and degenerative diseases associated with aging. The laboratory also has many collaborative interactions with investigators working the fields of oxygen toxicity, neurotoxicology, heavy metal toxicology, environmental toxicology, and hepatology. In this regard, the laboratory is a highly interdisciplinary research team, well integrated in many areas where oxidative stress and free radical biology potentially impact the biomedical research community.