The following vectors were constructed by John Engelhardt's laboratory. Please contact Dr. John Englehardt (john-engelhardt@uiowa.edu) for permission to obtain them from the Vector Core. In your email, please state briefly the intended use and relationships to any companies for MTA purposes. Please also cite the below references for the original construction of the vectors if your results are published.

NFκ dominant negative Adenoviruses

Ad.IKKbeta(K/A); Ad.IKKalpha(K/M)
Sanlioglu, S., C.M. Williams, et al. (2001). "Lipopolysaccharide induces Rac1-dependent reactive oxygen species formation and coordinates tumor necrosis factor-alpha secretion through IKK regulation of NK-kappa B." J Biol Chem 276(32): 30188-98.

Ad.IkBalpha(Y42F)
Fan, C., Li, Q., Zhang, Y., Liu, X., Luo, M., Abbott, D., Zhou, W., and Englehardt, J.F. 2004. IkappaBalpha and IkappaBbeta possess injury context-specific functions that uniquely influence hepatic NF-kappaB induction and inflammation. J Clin Invest 113:746-755.

Ad.IkBalphaAS 
Fan, C., Yang, J., and Engelhardt, J.F. 2002. Temporal pattern of NFkappaB activation influences apoptotic cell fate in a stimuli-dependent fashion. J Cell Sci 115:4843-4853.

Reporter Adenoviruses

Ad.NFkB-luciferase
Sanlioglu, S., C.M. Williams, et al. (2001). "Lipopolysaccharide induces Rac1-dependent reactive oxygen species formation and coordinates tumor necrosis factor-alpha secretion through IKK regulation of NF-kappa B." J Biol Chem 276(32): 30188-98.