The following vectors were constructed by John Engelhardt's laboratory. Please contact Dr. John Englehardt (john-engelhardt@uiowa.edu) for permission to obtain them from the Vector Core. In your email, please state briefly the intended use and relationships to any companies for MTA purposes. Please also cite the below references for the original construction of the vectors if your results are published.

Redox Modulating Adenoviruses

Ad.Catalase
Lam, E. W., R. Zwacka, et al. (1999). "Effects of antioxidant enzyme overexpression on the invasive phenotype of hamster cheek pouch carcinoma cells." Free Radic Biol Med 27(5-6): 572-9.

Ad.GPx1
Li, Q., S. Sanlioglu, et al. (2001). "GPx-1 gene delivery modulates NFkappaB activation following diverse environmental injuries through a specific subunit of the IKK complex." Antioxid Redox Signal 3(3): 415-32.

Ad.Cu/ZnSOD
Zwacka, R. M., W. Zhou, et al. (1998). "Redox gene therapy protects human IB-3 lung epithelial cells against ionizing radiation-induced apoptosis." Hum Gene Ther 9(9): 1381-6.

Ad.MnSOD
Zwacka, R. M., W. Zhou, et al. (1998). "Redox gene therapy for ischemia/reperfusion injury of the liver reduces AP1 and NK-kappaB activation." Nat Med 4(6): 698-704.

AdN17Rac1 and AdwtRac1
Requirement for Rac1-dependent NADPH oxidase in the cardiovascular and dipsogenic actions of AngII in the Brain. Zimmerman, Dunlay, Lazartigues, Zhang, Sharma, Englehardt, Davisson. Circ. Res. 2004;95:532-539.