Cancer and Tumor Modeling and Simulation
Time & Place: TBD Instructor: Jun Ni, Ph.D., Associate Professor Department of Radiology, Carver College of Medicine, Biomedical Engineering Mechanical Engineering University of Iowa, Iowa City, IA, USA Tel: (319) 335-9490 E-mail: jun-ni@uiowa.edu Office Hours and Place: Textbook: Luigi Preziosi Ed. , "Cancer Modeling and Simulation ," First Edition, Chapman & Hall/CRC, 2005.         Class Lecture Notes: Additional notes or handouts may be available in classroom. Course Description: Tumour evolution is a complex process involving many different phenomena. Mathematical modelling and computer simulations can help us understand these phenomena, but their development requires a multidisciplinary background-one that includes an understanding of the biological phenomena involved and knowledge of the mathematical techniques used to obtain both qualitative and quantitative results. Cancer Modelling and Simulation builds the requisite biological foundation and presents the mathematical models and methods most useful for understanding the dynamics of tumour development and growth. This course is intended to introduce an interdisciplinary team of leading researchers about the entire modelling process, from phenomenological observation to simulation and validation, through the development of mathematical models and their qualitative and quantitative study. Teh course covers the analytical, mathematical, and biological aspects of tumour growth modelling to provide researchers from multiple disciplines with the common language and practical knowledge they need to break down the barriers that can hamper interdisciplinary research. The course is desgined for graduate students or researchers in mathematical modeling of computational biomedicine. Pre-requisites: TBD Course Contents: Biological Aspects of Tumor Angiogenesis Novel Directions in tumor Biology Interstitial Transport in Solid Tumor Modeling Avascular Tumor Growth Modeling of Vascular Tumor Growth Modeling of Tumor-induced Angiogenesis Multi-scale Analysis of Angiogenic Dynamics and Therapy Adhesion Mechanisms in Cancer Metastasis Static and Dynamic Interaction between Endothelium and Circulating Cells Mathematical Modeling of Tissue Invasion Cancer Immune System Competition Analysis Hypersensitivity to Chemotherapy in a Cellular Automata Model of the Immune System Reaction-Diffusion System

 

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