Introduction to Biomedical Optics

Time & Place:
TBD

Instructor:
Jun Ni, Ph.D., Associate Professor
Department of Radiology, Carver College of Medicine,
Biomedical Engineering
Mechanical Engineering
University of Iowa, Iowa City, IA, USA
Tel: (319) 335-9490
E-mail: jun-ni@uiowa.edu

Office Hours and Place:
TBD

Textbook:
R. Splinter and B A Hooper, "An Introduction to Biomedical Optics," First Edition, Taylor & Francis, 2007.

 

 

 

 

Class Lecture Notes:
Additional notes or handouts may be available in classroom.

Course Description:

Pre-requisites:
TBD

Goals and Objectives:
The course is designed for physics and/or other non-scientist professionals.

Course Contents:

  1. General Biomedical Optics Theory
    1. Introduction to Light for Diagnostic and Therapeutic Modalities
      1. What is biomedical Optics?
      2. Biomedical Optics Timeline
      3. Historical Events in Therapeutic and Diagnostic use of Light
      4. Light Sources
    2. Optical Principles: Fundamental Electromagnetic Theory and Description of Light Sources
      1. Definitions in Optics
      2. Kirchhoff's laws of Radiation
      3. Electromagnetic Wave Theory
      4. Light Sources
      5. Applications of Various Lasers
    3. Optical Principles: Classical Optics
      1. Geometrical Optics
      2. Other Optical Principles
      3. Quantum Physics
      4. Gaussian Optics
    4. Optical Interaction Properties
      1. Absorption and Scattering
      2. Doppler Effect
    5. Light-Tissue Interaction Variables
      1. Laser Variables
      2. Tissue Variables
      3. Light Transportation Theory
      4. Light Propagation under Dominant Absorption
    6. Light-Tissue Interaction Theory
      1. Approximations of The Equation of Radiative Transport
    7. Numerical and Deterministic Methods in Light-Tissue Interaction Theory
      1. Numerical Method to Solve the Equation of ra Transport
      2. measurement of Optical Parameters
      3. Temperature Effects of Light-Tissue Interaction
    8. Light-Tissue Interaction Mechanisms and Applications: Photophysical
      1. Range of Photophysical Mechanisms
      2. Photoablation
      3. Photoaccounstics
      4. Birefringence Effects
      5. Polarization Effects
      6. Optical Activities
      7. Evanescent Wave Interaction in Biomedical Optics
      8. Phase Interference Effects
      9. Spectroscopy
      10. Endoscope
    9. Light-Tissue Interaction Mechanisms and Applications: Photochemical
      1. Basic Photochemical Principles
      2. Photochemical Effects
    10. Light-Tissue Interaction Mechanisms and Applications: Photobiological
      1. Photobiological Biostimulation
      2. Photobiological Effects
      3. Excitation of Chromophores
      4. Optical Nerve-cell Depolarization under the Influence of Light
  2. Therapeutic Applications of Light
    1. Therapeutic Applications of Light: Photophysical
      1. Delivery considerations
      2. Pulsed Laser Use in Cardiology
      3. Density and oral Surgery
      4. Ophthalmology
      5. Optical Tweezers
    2. Therapeutic Applications of Light: Photochemical
      1. Vascular Welding
      2. Cosmetic Surgery
      3. Oncology
    3. Therapeutic Applications of Light: Photobiological
      1. Cardiology and Cardiovascular Surgery
      2. Soft Tissue Treatment
      3. Dermatology
      4. Fetal Surgery
      5. Gastroenterology
      6. General Surgery
      7. Gynecology
      8. Neurosurgery
      9. Ophthalmology
      10. Pulmonology and Otohinolaryngology
      11. Otolaryngology, Ear, Nose and Throat (ENT), and Maxillofacial Surgery
      12. Podiatry
      13. Urology
  3. Diagnostic Applications of Light
    1. Diagnostic Methods Using Light: Photophysical
      1. Optical Microscopy
      2. various Microscopic techniques
      3. Near-field scanning Optical Microscope
      4. Spectral Range Diagnostics
      5. Holographic Imaging
      6. Polarization Imaging
      7. Transillumination Imaging
      8. Optical Coherence Tomography
      9. Ballistic Photon Imaging
      10. Reflectometry
      11. Evanescent Wave Imaging Applications
      12. Medical Thermography
      13. Photoaccoustic Imaging
      14. Terahertz Imaging
    2. Diagnostic Methods Using Light: Photochemical
      1. Fluorescence Imaging
      2. Radio Fluorescence Microscopy
      3. Raman Spectroscopy with Near-field Scanning Optical Microscopy (NSOM) Employed
      4. Optical "Tongue"
    3. Diagnostic Methods Using Light: Photobiological
      1. Immunostaining
      2. Immunofluorescence
      3. Diagnostic Applications of Spectroscopy
      4. Fiberoptical Sensors
      5. Optical Coherence Tomography in Density
      6. Optical Biospy
      7. Determination of Blood Oxygenation
      8. Electroluminescence Electrophysiologic Mapping
        1. Quantum Dots as Biological Fluorescence Markers
      9. Compilation of Optical Requirements of Wavelength Selection based on the Desired Effects
 

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