Reviews
T Cell
1. van Parijs, L., Perez, VL, and Abbas, AK. Mechanisms of peripheral T cell tolerance. Immunological Tolerance by Wiley, Chichester, pp 5-20, 1998.

2. Abbas, A.K. The control of T cell activation vs. tolerance. Autoimmunity Reviews, pp 115-118, 2003.

3. Jiang, S., and Lechler, R.I. Regulatory T cells in the control of transplantation tolerance and autoimmunity. Amer. J. Transplant. 3:516-524, 2003.

4. Gad, M., Claesson, M.H., and Pedersen, A.E. Dendritic cells in peripheral tolerance and immunity. APMIS 111:766-775, 2003.

5. Ramsdell, F. Foxp3 and natural regulatory T cells: Key to a cell lineage. Immunity. 19:165-168, 2003.

B Cell
6. Goodnow CC. Glimpses into the balance between immunity and self-tolerance. [Review] Ciba Foundation Symposium. 204:190-202; discussion 202-207, 1997.

7. Glynne, R., Ghandour, G., Rayner, J., Mack, D.H., and Goodnow, C.C. B-lymphocyte quiescence, tolerance and activation as viewed by global gene expression profiling on microarrays. Immunological Reviews 176:216-246, 2000.

Primary Literature for Special Emphasis (extra reading encouraged)
T Cell – Lecture 1
1. Taams, LS, van Eden, W, and Wauben, MHM. Dose-dependent induction of distinct anergic phenotypes: Multiple levels of T cell anergy. J. Immunol. 162:1974-1981, 1999.

2. Anderson, MS, Venanzi, ES, Klein, L, Chen, Z, Berzins, SP, Turley, SJ, von Boehmer, H, Bronson, R, Dierich, A, Benoist, C, and Mathis, D. Projection of an immunological self shadow within the thymus by the Aire protein. Science 298:1395-1401, 2002.

3. Derbinski, J., Schulte, A., Kyewski, B., and Klein, L. Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self. Nature Immunol. 2:1032-1039, 2001.

4. Tzachanis, D, Freeman, GJ, Hirano, N, van Puijenbroek, AAFL, Delfs, MW, Berezovskay, A, Nadler, LM, and Boussiotis, VA. Tob is a negative regulator of activation that is expressed in anergic and quiescent T cells. Nature Immunol. 2:1174-1182, 2001.

B Cell – Lectures 2 & 3
5. Cooke, MP, Heath, AW, Shokat, KM, Zeng, Y, Finkelman, FD, Linsley, PS, Howard, M and Goodnow, CC. Immunoglobulin signal transduction guides the specificity of B cell-T cell interactions and is blocked in tolerant self-reactive B cells. J. Exp. Med. 179:425-438, 1994.

6. Healy, JI, Dolmetsch, RE, Timmerman, LA, Cyster, JG, Thomas, ML, Crabtree, GR, Lewis, RS, and Goodnow, CC. Different nuclear signals are activated by the B cell receptor during positive versus negative signaling. Immunity 6:419-428, 1997.

7. Prodeus, AP, Goerg, S, Shen, L-M, Pozdnyakova, OO, Chu, L, Alicot, EM, Goodnow, CC, and Carroll, MC. A critical role for complement in maintenance of self-tolerance. Immunity 9:721-731, 1998.

Autoimmunity – Lectures 4 & 5
8. Gao, Y, Herndon, JM, Zhang, H, Griffith, TS, and Ferguson, TA. Antiinflammatory effects of CD95 ligand (FasL)-induced apoptosis. J. Exp. Med. 188:887-896, 1998.

9. Arbuckle, MR, Reichlin, M, Harley, JB, and James, JA. Shared early autoantibody recognition events in the development of anti-Sm B/B’ in human lupus. Scand. J. Immunol. 50:447-455, 1999.

10. Yoon, J-W, Yoon, C-S, Lim, H-W, Huang, QQ, Kang, Y, Pyun, KH, Hirasawa, K, Sherwin, RS, and Jun, H-S. Control of autoimmune diabetes in NOD mice by GAD expression or suppression in ? cells. Science 284:1183-1187, 1999.