Required Reading:
Brief overview of cell surface proteolytic processing as a mechanism of regulation of membrane receptors and other membrane proteins:
Werb, Z., and Y.B. Yan. 1998. A cellular striptease act. Science 282:1279. (pdf on web site)
(You may want to view the original of this at the Science web site, since the figures do not show well in the converted pdf file.)
Optional Reading:
TNF-alpha converting enzyme (TACE) knockout mice:
Peschon, J. J. et al. 1998. An essential role for ectodomain shedding in mammalian
development. Science 282:1281.
The best general reviews of receptor proteolytic shedding, including information
on structureal features that render proteins susceptible to cleavage and the
role of APP cleavage in Alzheimer's disease:
Hooper, N. M., E. H. Karran, and A. J. Turner. 1997. Membrane protein secretases.
Biochemical Journal 321:265.
Schlondorff, J., and C. P. Blobel. 1999. Metalloprotease-disintegrins: modular proteins capable of promoting cell-cell interactions and triggering signals by protein-ectodomain shedding. J. Cell Science 112:3603.
Review of the Regulation of Adhesion Molecule Expression During T Cell Differentiation,
including a review of L-selectin shedding:
Dailey, M. O. 1998. Expression of T lymphocyte adhesion molecules: regulation
during antigen-induced T cell activation and differentiation. Crit. Rev. Immunol.
18:153.
(Reprint located in the file in the Immunology Library)
Experiments using aly and Hox-11 knockout mice to examine the role of central
vs. peripheral T cell sensitization: