Reading List for Thursday February 5, 2004


Required Reading: (pdf file is on the Program web site)

Mechanisms by which chemokines cause the increase in adhesiveness of lymphocytes to ICAM-1, involving both changes in affinity and in the topological organization of lymphocyte surface integrin:

Constantin, G., M. Meytham, G. C., L. Piccio, J.-Y. Kim, E. C. Butcher, and C. Laudanna. 2000. Chemokines Trigger Immediate Beta2 Integrin Affinity and Mobility Changes: Differential Regulation and Roles in Lymphocyte Arrest under Flow. Immunity 13:759.

Optional Reading:

Good general overview of chemokines and their receptors, including the newer nomenclature:

Olson, T.S., and K. Ley. 2002. Chemokines and chemokine receptors in leukocyte trafficking. American Journal of Physiology - Regulatory Integrative & Comparative Physiology 283:R7-28. (pdf on web site)

Dominant role of LFA-1 clustering in the increased avidity of LFA-1-mediated adhesion induced by PMA or through TCR signaling (referenced repeatedly in the Constantin paper above):

Stewart, M. P., A. McDowall, and N. Hogg. 1998. LFA-1-mediated adhesion is regulated by cytoskeletal restraint and by a Ca2+-dependent protease, calpain. J. Cell Biol. 140:699.
(pdf on web site)

The chemokine BLC and its receptor, CCR5 induces the migration of B cells into lymphoid follicles, thereby being a major factor in organizing the architecture of B cell areas:

Ansel, K. M., V. N. Ngo, P. L. Hyman, S. A. Luther, R. Forster, J. D. Sedgwick, J. L. Browning, M. Lipp, and J. G. Cyster. 2000. A chemokine-driven positive feedback loop organizes lymphoid follicles. Nature 406:309. (pdf on web site)

Differential chemokine receptor expression and the selective targeting of Th1 and Th2 cells to sites of inflammation:

Randolph, D.A., G.M. Huang, C.J.L. Carruthers, L.E. Bromley, and D.D. Chaplin. 1999. The role of CCR7 in T(H)1 and T(H)2 cell localization and delivery of B cell help in vivo. Science 286:2159.

Chemokines and the specific recognition of subsets of memory T cells:

Campbell, J.J., G. Haraldsen, J. Pan, J. Rottman, S. Qin, P. Ponath, D.P. Andrew, R. Warnke, N. Ruffing, N. Kassam, L. Wu, and E.C. Butcher. 1999. The chemokine receptor CCR4 in vascular recognition by cutaneous but not intestinal memory T cells. Nature 400:776.

Involvement of a recently described chemokine in promoting the entry of a specific subset of inflammatory lymphocytes into a single anatomic site, the skin:

Morales, J., B. Homey, A.P. Vicari, S. Hudak, E. Oldham, J. Hedrick, R. Orozco, N.G. Copeland, N.A. Jenkins, L.M. McEvoy, and A. Zlotnik. 1999. CTACK, a skin-associated chemokine that preferentially attracts skin-homing memory T cells. Proc. Natl. Acad. Sci. 96:14470. (pdf on web site)