JON HEUSEL READING LIST, February 17 and 19

REQUIRED READING:

The following provides a good overview of NK cells relevant to the whole three-lecture series:

Immunobiology/Janeway, 5th ed. (2001)

chapter 2-25 thru 2-28 pp. 81-88 Innate immunity; NK cells
chapter 5-10 thru 5-12 pp. 169-173 MHC class I and related ligands for NK cell receptors
chapter 8-6 & 8-7 pp. 307-311 Dendritic cells and macrophages
chapter 9-19 thru 9-21 pp. 370-373 Fc receptors and ADCC (NK cells)

Required Reading for the First Two Lectures:

Tuesday, Feb 17th: Viral pathogens, Toll-like receptors and detection of microbes, and cellular components of the early immune response - NK cells, NK-T cells, and dendritic cells (DC):

Kopp, E. and Medzhitov, R. Recognition of microbial infection by Toll-like receptors. Curr Opin Immunol. 2003. Aug;15(4):396-401. (Review)

Colucci F, Caligiuri MA, Di Santo JP. What does it take to make a natural killer? Nat Rev Immunol. 2003 May;3(5):413-25.

Lund J, Sato A, Akira S, Medzhitov R, Iwasaki A. Toll-like receptor 9-mediated recognition of Herpes simplex virus-2 by plasmacytoid dendritic cells. J Exp Med. 2003 Aug 4;198(3):513-20.

Thursday, Feb 19th: The immune response to herpesviruses--an example of host-pathogen detente:

Orange JS, Fassett MS, Koopman LA, Boyson JE, Strominger JL. Viral evasion of natural killer cells. Nat Immunol. 2002 Nov;3(11):1006-12. (Review)

Arase H, Mocarski ES, Campbell AE, Hill AB, Lanier LL. Direct recognition of cytomegalovirus by activating and inhibitory NK cell receptors. Science. 2002 May 17; 296(5571):1323-6.

Suggested/Optional Reading:
Fundamental Immunology/ W. Paul, 5th ed. (2003)
chapter 12: Natural Killer Cells pp. 365-87
chapter 15: Dendritic Cells pp. 455-75
chapter 19: MHC Complex and Encoded Proteins pp. 589-90; 600-601
chapter 39: Viral Immunology pp. 1201-23
chapter 48: Tumor Immunology pp. 1557-89

Journal Articles:

Cooper MA, Fehniger TA, Caligiuri MA: The biology of human natural killer-cell subsets. Trends Immunol 2001, 22:633-640. (review)

Emoto M, Kaufmann SH. Liver NKT cells: an account of heterogeneity. Trends Immunol.
2003 Jul;24(7):364-9. (review)

Takeda K, Kaisho T, Akira S. Toll-like receptors. Annu Rev Immunol. 2003;21:335-76. (review)

van den Berg TK, Yoder JA, Litman GW. On the origins of adaptive immunity: innate immune receptors join the tale. Trends Immunol. 2004 Jan;25(1):11-6. (review)

Biron CA, Brossay L: NK cells and NKT cells in innate defense against viral infections. Current Opinion in Immunology. 2001, 13:458-464. (review)

Orange JS: Human natural killer cell deficiencies and susceptibility to infection. Microbes & Infection 2002, 4:1545-1558 (review).

Heusel JW and Ballas ZK. Natural killer cells: emerging concepts in immunity to infection and implications for assessment of immunodeficiency. Curr Opin Pediatr. 2003 Dec;15(6):586-93 (review)

Andrews DM, Andoniou CE, Granucci F, Ricciardi-Castagnoli P, Degli-Esposti MA. Infection of dendritic cells by murine cytomegalovirus induces functional paralysis. Nat Immunol. 2001 Nov; 2(11): 1077-84.

Andrews DM, Scalzo AA, Yokoyama WM, Smyth MJ, Degli-Esposti MA. Functional interactions between dendritic cells and NK cells during viral infection. Nat Immunol. 2003 Feb; 4(2): 175-81.