Immunology II
Mary Wilson
April 8-20, 2004: T Cell Differentiation
T Cell Development
April 8
Required Readings:
Liew FY. TH1 and TH2 cells: a historical perspective. Nature Reviews Immunology
2:55-60.
Usui T, R Nishikomori, A Kitani, and W Strober. GATA-3 suppresses Th1 development
by down-regulation of Stat4 and not through effects of IL-12R?2 chain or T-bet.
Immunity 18:415-428, 2003.
April 13
Required Readings:
Ho I-C and LH Glimcher. Transcription: tantalizing times for T cells. Cell
109:S109-S120.
Lee GR, PE Fields, TJ Griffin IV, and RA Flavell. Regulation of the Th2 cytokine
locus by a locus control region. Immunity 19:145-153, 2003.
(companion editorial
for the Lee article) Smale ST. A Th2 cytokine
LCR: adding a new piece to the regulatory puzzle. Immunity 19:1-2, 2003.
Optional Readings:
Pearce EL, AC Mullen, GA Martins, CM Krawczyk, AS Hutchins, VP Zediak, M Banica,
CB DiCioccio, DA Gross, C-a Mao, H Shen, N Cereb, SY Yang, T Lindsten, J Rossanty,
CA Hunter, and SL Reiner. Control of effector CD8+ T cell function by the transcription
factor Eomesodermin. Science 302(7):1041-1043.
(companion editorial for Pearce article) Hatton RD and
CT Weaver. T-bet or not T-bet. Science 302(7):993-994, 2003.
April 15
Required Readings:
Shevach EM., CD4+CD25+ suppressor T cells: more questions than answers. Nature
Reviews 2:389-400, 2002.
Optional Readings:
Neurath, M. F., B. Weigmann, S. Finotto,
J. Glickman, E. Nieuwenhuis, H. Iijima, A. Mizoguchi, E. Mizoguchi, J.
Mudter, P. R. Galle, A. Bhan,
F. Autschbach,
B. M. Sullivan, S. J. Szabo, L. H. Glimcher, R. S. Blumberg. The transcription
factor T-bet regulates mucosal T cell activation in experimental colitis
and Crohn’s disease. J. Exp. Med. 195 (9):1129-1143, 2002.
S Hori, T Nomura, S Sakaguchi. Control of regulatory T cell development by
the transcription factor Foxp3. Science 299:1057, 2003
Immunoparasitology
April 20
Required Readings:
Sacks D and N Noben-Trauth. The immunology of susceptibility and resistance
to Leishmania major in mice. Nature Reviews Immunology 2:845-858, 2002.
Yazdanbakhsh M., PG Kremsner and R van Ree. Allergy, parasites, and the hygiene
hypothesis. Science 296:490-494, 2002.
Belkaid Y, KF Hoffmann, S Mendez, S Kamhavi, TA Wynn, and D Sacks. 2001. The
role of interleukin (IL)-10 in the persistence of Leishmania major in the skin
after healing and the therapeutic potential of anti-IL-10 receptor antibody
for sterile cure. J. Exp. Med. 194:1497-1506.
Optional Readings:
(companion editorial with Belkaid
article) Trinchieri G. Regulatory role of T cells producing both Interferon
gamma and interleukin 10 in persistent
infection.
2001. J. Exp. Med. 194 (10):F53-F57.
Cervi L, AS MacDonald, C Kane, F Dzierszinski, EJ Pearce. Cutting edge: Dendritic
cells copulsed with microbial and helminth antigens undergo modified maturation,
segregate the antigens to distinct intracellular compartments, and concurrently
induce microbe-specific Th1 and helminth-specific Th2 responses. J. Immunology
172:2016-2020, 2004.
Vaccine Development
April 22, 2004
Required Readings:
1. Janeway CA, P Travers, M Walport, MJ Shlomchik (editors); “Immunobiology:
The Immune System in Health and Disease”, volume 5, 2001. Chapter 14-16
through 14-28, pages 577-591.
2. Uzonna JE, G Wei, D Yurkowski, P Bretscher. Immune elimination of Leishmania
major in mice: implications for immune memory, vaccination, and reactivation
disease. J. Immunol. 167:6967-6974, 2001.