Kevin C. Kregel, Ph.D.

Departmental Executive Officer

Professor: Departments of Integrative Physiology and Radiation Oncology (Free Radical & Radiation Biology Program)

Doctoral Degree: Physiology & Biophysics
Institution: The University of Iowa (1987)

Office: 424 Field House
Office: Phone: (319) 335-7596
e-mail:  kevin-kregel@uiowa.edu

Specialization: Integrative Physiology, Exercise Physiology

Courses Taught:

27:130 Human Physiology
27:141 Exercise Physiology
27:241 Integrative Physiology Seminar
50:240 Human Organ Systems

Research Interests:

Studies in this laboratory are designed to elucidate the systemic, cellular, and molecular mechanisms by which an organism copes with various stresses (e.g., oxidants, heat, hypoxia), with a primary emphasis on factors contributing to the changes in stress tolerance that accompany biological aging. Areas of focus include:

1. Basic mechanisms of the stress response, including stress protein and free radical regulation, the potential beneficial or deleterious role of these proteins in regulating response to a variety of environmental stimuli, and the effect of aging on these responses;

2. The impact of oxidative stress on physiological function and its role in pathophysiological changes with aging and disease conditions;

3. Mechanisms responsible for stress-induced regulation of cardiovascular, thermoregulatory, metabolic, endocrine and neuromuscular systems at the whole animal, cellular, molecular and genetic levels.

Recent Publications:

Kregel KC and Zhang HJ. (Invited Review) An Integrated View of Oxidative Stress in Aging: Basic Mechanisms, Functional Effects and Pathological Considerations. Am J Physiol: Regul Integr Comp Physiol. 292: R18-R36, 2007.

Bloomer SA, Brown KE, Buettner GA, and Kregel KC. Dysregulation of hepatic iron with aging: implications for heat stress-induced oxidative liver injury. Am J Physiol: Regul Integr Comp Physiol. 294: R1165-74, 2008.

Oberley TD, Swanlund JM, Zhang HJ, and Kregel KC. Aging results in increased autophagy of mitochondria and protein nitration in rat hepatocytes following heat stress. J Histochem Cytochem. 56: 615-27, 2008.

Haak J and Kregel KC. 1962-2007: A cell stress odyssey. Novartis Found Symp 291:3-15, 2008.

Haak JL, Spitz DR, Buettner GA, and Kregel KC. Aging augments mitochondrial susceptibility to environmental stress. Am J Physiol: Regul Integr Comp Physiol 296:R812-20, 2009.