27:130 Human Physiology
27:146 Molecules to Malady
27:241 Integrative Physiology Seminar
27:245 Advanced Exercise Physiology

Research Interests:
Studies in our laboratory center on understanding how bone marrow-derived stem cells, help repair and maintain blood vessels, and the consequences of stem cell dysfunction on vascular physiology.  Bone marrow cells move into the blood and these circulating cells appear to be important both in minor repair of blood vessels and in the formation of new blood vessels. Since they were only recently identified in adults, little is known about their basic biology.  One area of research in the laboratory is to delineation of chemical, metabolic, and physical factors that control circulating stem cell growth and differentiation.  People with diabetes are more susceptible to cardiovascular disease than are non-diabetic people, and diabetes appears to impair stem cell function.  Hence, a second focus of the laboratory is to delineate the mechanisms by which diabetes alters stem cell function, and to determine if stem cell dysfunction is in part responsible for severe cardiovascular disease associated with diabetes.  In support of this hypothesis, we have shown, that treatment with circulating stem cells significantly accelerates the restoration of blood flow to the limbs of diabetic, but not non-diabetic mice suffering from circulatory impairment.  Our ultimate goal is to provide a framework whereby clinicians can devise means to manipulate and/or transplant blood or bone marrow stem cells to treat vascular disease in diabetic patients. The laboratory is currently funded by grants from the National Institutes of Health, the Juvenile Diabetes Research Foundation, and the American Diabetes Association. Dr. Schatteman is seeking PhD candidates for the academic year 2006-2007.  Successful applicants are typically supported during the academic year through, a half-time PhD teaching assistant (TA) or research assistant (RA) stipend. Summer stipends are also available. For academic year 2005-2006, all PhD students received full tuition scholarships in addition to their TA/RA stipends.

Selected Recent Publications
Awad O, Dedkov EI, Jiao C, Bloomer S, Tomanek RJ, and G.C. Schatteman . (2006) Differential healing activities of CD34+ and CD14+ endothelial cell progenitors. Arterioscler Thromb Vasc Biol., 26:758-764.

Awad, O., Jiao, C., Ma, N. Dunnwald, M., and G.C. Schatteman.  (2005) The obese diabetic mouse environment differentially affects primitive and monocytic endothelial cell progenitors. Stem Cells 23:575-583.

Wang, C., Jiao, C., Hanlon, H.D., Zheng, R.J., and G.C. Schatteman.  (2004)  Mechanical, cellular, and molecular factors interact to modulate circulating endothelial cell progenitors. Am. J. Physiol., Heart Circ. Physiol., 286:H1985-1933.

Sivan-Loukianova, E. Awad, O., Stepanovic, V., Bickenbach, J., and G.C. Schatteman. (2003) Circulating CD34 + cells accelerate vascularization of diabetic skin wounds, J Vasc Res., 40: 368-77.

Stepanovic, V., Awad, O., Jiao, C., Dunnwald, M., and G.C. Schatteman. (2003) Leprdb diabetic mouse bone marrow cells inhibit skin wound vascularization but promote wound healing, Circ. Res., 92:1247-53.

Crosby, J.R., Kaminski,W.E., Schatteman, G.C., Martin, P.J., Raines, E.W., Seifert R.A., and D.F.Bowen-Pope (2000).   Endothelial cells of hematopoietic origin make a significant contribution to adult blood vessel formation. Circ. Res. 87:728-730.

Schatteman, G.C, Hanlon, H., Jiao, C., Dodds, S.G and B.A. Christy (2000).  Blood-derived angioblasts accelerate blood flow restoration in diabetic mice. J. Clin. Invest. 106: 571-578.

Asahara, T., Murohara, T. Sullivan, A. Silver, M., van der Zee, R.,  Li, T., Witzenbichler, B., Schatteman, G.C. and J.M. Isner (1997).  Isolation of putative progenitor endothelial cells for angiogenesis. Science,
275:964-967.

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