Program Publications

 

2008
Gregor Luthe, Regine Boy, James Jacobus, Brian Smith, Asif Rahaman, Larry W. Robertson, and Gabriele Ludewig. Xenobiotic Geometry and Media pH determine Cytotoxicity through Solubility. Chem. Res. Toxicol. In Press

H.J. Lehmler, L. Xu, S.M. Vyas, V.A. Ojogun B.L. Knutson and G. Ludewig. Synthesis, Physicochemical Properties and In Vitro Cytotoxicity of Nicotinic Acid Ester Prodrugs Intended for Pulmonary Delivery Using Perfluorooctyl Bromide as Vehicle. Journal of Pharmaceutics, Vol 353 (1-2), 35-44, 2008. Abstract

C. Maddox, B. Wang, P.A. Kirby, K. Wang, and G. Ludewig. Mutagenicity of 3-methylcholanthrene, PCB3, and 4-OH-PCB3 in the lung of transgenic BigBlue® rats. Environmental Toxicology and Pharmacology, Vol 25 (2), 260-266, 2008. Abstract

E.L. Gregoraszczuk, A. Rak, G. Ludewig and A. Gasin´ska. Effects of estradiol, PCB3, and their hydroxylated metabolites on proliferation, cell cycle, and apoptosis of human breast cancer cells. Environmental Toxicology and Pharmacology, Vol 25 (2), 227-233, 2008. Abstract

J. Klösener, D. C. Swenson, L. W. Robertson and G. Luthe. Effects of fluoro substitution on 4-bromodiphenyl ether (PBDE 3). Acta Cryst. B64, 108–119 (2008). Abstract

J.C. Sacco, H.-J. Lehmler, L.W. Robertson, W. Li, and M.O. James. Glucuronidation of polychlorinated biphenylols and UDPGA concentration in channel catfish liver and intestine. Drug Metabolism and Disposition 36, 623–630 (2008). Abstract

D.N. Stemm, J.C. Tharappel, H.-J Lehmler, C. Srinivasan, J. S. Morris, V.L. Spate, L.W. Robertson, B.T. Spear and H.P. Glauert. Effect of Dietary Selenium on the Promotion of Hepatocarcinogenesis by 3,3’,4,4’-Tetrachlorobiphenyl and 2,2’,4,4’,5,5’-Hexachlorobiphenyl. Exp. Biol. Med. 233, 366–376 (2008). Abstract

I. Kania-Korwel, K.C. Hornbuckle, L.W. Robertson, and H.-J. Lehmler. Influence of dietary fat on the enantioselective disposition of 2,2',3,3',6,6'-hexachlorobiphenyl (PCB 136) in female mice. Food and Chemical Toxicology 46, 637–644 (2008). Abstract

I. Kania-Korwel, K. Hornbuckle, L. Robertson, H.-J. Lehmler, Dose-Dependent Enantiomeric Enrichment of 2,2',3,3',6,6'-Hexachlorobiphenyl in Female Mice. Environ Toxicol Chem. 27, 299-305 (2008). Abstract

L.W. Robertson, W. Sulkowski and B. Hennig, Preface. Special Issue of ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY, FOCUS ON PCBs: RECENT ADVANCES IN ENVIRONMENTAL DISTRIBUTION AND HEALTH EFFECTS, Guest Editors: Larry Robertson, Wieslaw Sulkowski and Bernhard Hennig, Vol. 25, issue 2 March 2008, 127.

G. Luthe, J.A. Jacobus and L.W. Robertson, Receptor interactions by polybrominated diphenyl ethers versus polychlorinated biphenyls: A theoretical structure–activity assessment. Environmental Toxicology and Pharmacology 25, 202-210 (2008). Abstract

G. Ludewig, L. Lehmann, H. Esch and L.W. Robertson, Metabolic activation of PCBs to carcinogens in vivo—A review. Environmental Toxicology and Pharmacology 25, 241-246 (2008). Abstract

H.P. Glauert, J.C. Tharappel, Z. Lu, D. Stemm, S. Banerjee, L.S. Chan, E.Y. Lee, H.-J. Lehmler, L.W. Robertson and B.T. Spear, Role of oxidative stress in the promoting activities of PCBs. Environmental Toxicology and Pharmacology 25, 247-250 (2008). Abstract

J.A. Jacobus, S. Flor, A.J. Klingelhutz, L.W. Robertson and G. Ludewig, 2-(4-chlorophenyl)-1,4-benzoquinone increases the frequency of micronuclei and shortens telomeres. Environmental Toxicology and Pharmacology 25, 267-272 (2008). Abstract

S. Ravoori, P. Ayotte, C. Srinivasan, D. Pereg, L.W. Robertson, G.K. Russell, J. Jeyabalan and R.C. Gupta, DNA damage associated with PCBs in the whole blood cells of Inuit. Environmental Toxicology and Pharmacology 25, 273-276 (2008). Abstract

S. Telu, S. Parkin, L.W. Robertson, H.-J. Lehmler, 1,3,5-Trichloro-2-methoxybenzene. Acta Cryst. E 2008: 64, o424. Full-text PDF

2007

L. W. Robertson, I. Berberian, T. Borges, L. Chen, C.K. Chow, H.P. Glauert, J.G. Filser and H. Thomas. Suppression of peroxisomal enzyme activities and cytochrome P-4504A isozyme expression by congeneric polybrominated and polychlorinated biphenyls. PPAR Research, vol. 2007, Article ID 15481, 5 pages, 2007. doi:10.1155/2007/15481. Open Access PDF

M.A. Zettner, S. Flor, G. Ludewig, J. Wagner, L.W. Robertson, L. Lehmann. Quinoid Metabolites of 4-monochlorobiphenyl (PCB3) Induce Gene Mutations in Cultured Chinese Hamster V79 Cells. Toxicological Sciences 100, 88–98 (2007). Abstract

R.P. Bunaciu, J.C. Tharappel, H.-J. Lehmler, I. Korwel, L.W. Robertson, C. Srinivasan, B.T. Spear, and H.P. Glauert. The Effect of Dietary Glycine on the Hepatic Tumor Promoting Activity of Polychlorinated Biphenyls (PCBs) in Rats. Toxicology 239, 147–155 (2007). Abstract

H. Sadeghi-aliabadi, K. Chan, H.-J. Lehmler, L.W. Robertson, P.J. O’Brien, Molecular cytotoxic mechanisms of catecholic Polychlorinated Biphenyl metabolites in isolated rat hepatocytes, Chemico-Biological Interactions 167, 184-192 (2007). Abstract

G. Luthe, D. C. Swenson and L.W. Robertson, Influence of fluoro-substitution on the planarity of 4-chlorobiphenyl (PCB 3), Acta Crystallographica, Section B: Structural Science 63, 319-327 (2007). Abstract

G. Ludewig, H. Esch and L.W. Robertson, Polyhalogenierte Bi- und Terphenyle, Chapter 20, In: Dunkelberg, H., Gebel, T., Hartwig, A. (Editors) Handbuch der Lebensmitteltoxikologie, Wiley-VCH Weinheim, pages 1031-1094 (2007).

I. Kania-Korwel, N.S. Shaikh, K.C. Hornbuckle, L.W. Robertson, H.-J. Lehmler. Enantioselective disposition of PCB 136 (2,2’,3,3’,6,6’-hexachlorobiphenyl) in C57BL/6 mice after oral and intraperitoneal administration. Chirality 19, 56-66 (2007). Abstract

L. Lehmann, H.L. Esch, P.A. Kirby, L.W. Robertson, G. Ludewig. 4-Monochlorobiphenyl (PCB3) induces mutations in the livers of transgenic Fisher 344 rats. Carcinogenesis 28, 471–478 (2007). Abstract

R.P. Bunaciu, J.C. Tharappel, H.-J. Lehmler, I. Korwel, L.W. Robertson, C. Srinivasan, B.T. Spear, Howard P. Glauert, The effect of dietary glycine on the hepatic tumor promoting activity of polychlorinated biphenyls (PCBs) in rats. Toxicology 2007: 239: 147-155. Abstract

H. Sadeghi-aliabadi, K. Chan, H.-J. Lehmler, L.W. Robertson, P.J. O’Brien, Molecular cytotoxic mechanisms of catecholic polychlorinated biphenyl metabolites in isolated rat hepatocytes. Chem.-Biol. Interactions 2007: 167, 184-192. Abstract

Y. Song, S. Parkin, H.-J. Lehmler, 4-Bromo-2-chloro-1-methoxybenzene. Acta Cryst. E 2007: 63, o2091-o2092. Full-text PDF

I. Kania-Korwel, N.S. Shaikh, K.C. Hornbuckle, L.W. Robertson, H.-J. Lehmler, Enantioselective disposition of PCB 136 (2,2’,3,3’,6,6’-Hexachlorobiphenyl) in C57BL/6 mice after oral and intraperitoneal administration.  Chirality 2007: 19, 56-66. Abstract

L. Lehmann, H.L. Esch, P.A. Kirby, L.W. Robertson, G. Ludewig. 4-Monochlorobiphenyl (PCB3) induces mutations in the livers of transgenic Fisher 344 rats. Carcinogenesis 28, 471-478, 2007. Abstract

Gabriele Ludewig, Harald Esch and Larry W. Robertson, Polyhalogenierte Bi- und Terphenyle, Chapter 20, In: Dunkelberg, H., Gebel, T., Hartwig, A. (Editors) Handbuch der Lebensmitteltoxikologie, Wiley-VCH Weinheim, pages 1031-1094, 2007.


2006

Y. Liu, T.I. Apak, H.-J. Lehmler, L.W. Robertson, M.W. Duffel, Hydroxylated polychlorinated biphenyls are substrates and inhibitors of human hydroxysteroid sulfotransferase SULT2A1.  Chem. Res. Toxicol. 2006: 19, 1420-1425. Abstract

A. Ptak, G. Ludewig, M. Kapiszewska, Z. Magnowska, H.J. Lehmler, L.W. Robertson, E.L. Gregoraszczuk. Induction of cytochromes P-450, caspase-3 and DNA damage by PCB3 and its hydroxylated metabolites in porcine ovary. Toxicology Letters 166, 200-211, 2006. abstract

N.S. Shaikh, D.C. Swenson, H.-J. Lehmler, 2,3,6-Trichloroiodobenzene. Acta Cryst. E 2006: 62, o4672-o4673.

S.M. Vyas, S. Parkin, L.W. Robertson, H.-J. Lehmler. 2,5-Dichloro-4'-methoxybiphenyl. Acta Cryst. E 2006: 62, o4162–o4163. Full-text PDF (with permission from publisher)

S.M. Vyas, S. Parkin, L.W. Robertson, H-J. Lehmler. 4 -Chloro-2’,3’-dimethoxybiphenyl. Acta Crystallographica Section E E62, o3639–o3640 (2006). Full-text PDF (with permission from publisher)

Julia Strathmann, Michael Schwarz, Job C. Tharappel, Howard P. Glauert, Brett T. Spear, Larry W. Robertson, Klaus E. Appel, and Albrecht Buchmann. PCB 153, a non-dioxin-like tumor promoter, selects for ß-Catenin (Catnb) mutated mouse liver tumors. Toxicological Sciences. Epub ahead of print

Ryan P. Bender, Hans-Joachim Lehmler, Larry W. Robertson, Gabriele Ludewig and Neil Osheroff. Polychlorinated Biphenyl Quinone Metabolites Poison Human Topoisomerase IIa: Altering Enzyme Function by Blocking the N-Terminal Protein Gate. Biochemistry. Abstract

Izabela Kania-Korwel, A. Wayne Garrison, Jimmy K. Avants, Keri C. Hornbuckle, Larry W. Robertson, Wieslaw W. Sulkowski, and Hans-Joachim Lehmler, Distribution of Chiral PCBs in Selected Tissues in the Laboratory Rat. Environmental Science & Technology 40, 3704-3710 (2006). Abstract

G. Luthe, P.E.G. Leonards, G.S. Reijerink, H. Liu, J.E. Johansen, L.W. Robertson, Monofluorinated analogues of polybrominated diphenyl ethers (F-PBDEs) as analytical standards: Synthesis, NMR and GC-MS characterization and molecular orbital studies. Environmental Science & Technology 40, 3023-3029 (2006). Abstract

S. Kunz, H.-J. Schmitz, A. Buchmann, M. Schwarz, B. Schilling, O. Päpke, H.-J. Lehmler, L.W. Robertson and D. Schrenk. Tumor promoting potency of PCBs 28 and 101 in rat liver. Toxicology Letters 164, 133–143 (2006). Abstract

A. Ptak, G. Ludewig, L.W. Robertson, H.-J. Lehmler and E.L. Gregoraszczuk. In vitro exposure of porcine prepubertal follicles to 4-chlorobiphenyl (PCB3) and its hydroxylated metabolites: effects on sex hormone levels and aromatase activity. Toxicology Letters 164, 113–122 (2006). Abstract

L.-Q. Wang, H.-J. Lehmler, L.W. Robertson, and M.O. James. Polychlorobiphenylols are selective inhibitors of human phenol sulfotransferase 1A1 with 4-nitrophenol as a substrate. Chem.-Biol. Interactions 159, 235-246 (2006). Abstract