Program Publications

2009
P.A. Correa; L. Lin; C.L. Just; D. Hu; K.C. Hornbuckle; J.L .Schnoor; B. Van Aken. The Effects of Individual PCB Congeners on the Soil Bacterial Community Structure and the Abundance of Biphenyl Dioxygenase Genes. In Press, Environment International. 2009 Aug 27. [Epub ahead of print]. PMID: 19716603

K. Norström; G. Czub; M.S. McLachlan; D. Hu; P.S. Thorne; K.C. Hornbuckle. External exposure and bioaccumulation of PCBs in humans living in a contaminated urban environment. Environment International, 2009 Apr 23. [Epub ahead of print]. PMID: 19394084

H. Zhao, A. Adamcakova-Dodd, D. Hu, K.C. Hornbuckle, C.L. Just, L.W. Robertson, P.S. Thorne, H.-J. Lehmler. Development of a Synthetic PCB Mixture Resembling the Average Polychlorinated Biphenyl Profile in Chicago Air. Environment International 2009 Apr 16. [Epub ahead of print]. PMID: 19375801

W.D. Wombacher and K.C. Hornbuckle. Synthetic Musk Fragrances in a Conventional Drinking Water Treatment Plant with Lime Softening.SCE Journal of Environmental Engineering 2009, 135(11): 1192-1198. http://dx.doi.org/10.1061/(ASCE)EE.1943-7870.0000085.

A. Martinez, K. Norström, K. Wang, K.C. Hornbuckle. Polychlorinated biphenyls in the surficial sediment of Indiana Harbor and Ship Canal, Lake Michigan. Environment International, 2009 Mar 4. [Epub ahead of print]. PMID: 19268364

Y. Liu, J. Smart, Y. Song, H.-J. Lehmler, L.W. Robertson, M.W. Duffel. 2009. Structure-activity relationships for hydroxylated polychlorinated biphenyls as substrates and inhibitors of rat sulfotransferases and modification of these relationships by changes in thiol status. Drug Metabolism and Disposition, 2009 Feb 5. [Epub ahead of print]. PMID: 19196841 PMCID: PMC2677757 [Available on 2010/05/01]

O. Wangpradit, S. Mariappan, L. Teesch, K. Norstrom, M. Duffel, L.W. Robertson, G. Luthe. Oxidation of 4-chlorobiphenyl metabolites to electrophilic species by prostaglandin H synthase. Chem. Res. Toxicol. 2009 Jan: 22(1):64-71. PMID: 19105592, PMCID: PMC2637223 [Available on 2010/01/01]

I.N. Pessah, H.-J. Lehmler, L.W. Robertson, C.F. Perez, E. Cabrales, D. Bose, W. Feng. Enantiomeric specificity of (-)-2,2',3,3',6,6'-hexachlorobiphenyl toward ryanodine receptor types 1 and 2. Chem. Res. Toxicol. 2009: 2009 Jan;22(1):201-7. PMID: 18954145 PMCID: PMC2662366 [Available on 2010/01/01]

J.Kloesener, T. Peters, A. Dodd, L. Teesch, P.S. Thorne, L.W. Robertson, G. Luthe. Innovative application of Fluoro-tagging to trace airborne particulate and gas phase PBDE exposures. Chem. Res. Toxicol. 2009 Jan;22(1):179-86. PMID: 19111055

2008

C. Persoon, K.C. Hornbuckle. Calculation of passive sampling rates from both native PCBs and depuration compounds in indoor and outdoor environments. Chemosphere. 2009 Feb;74(7):917-23. Epub 2008 Dec 9. PMID: 19068264, PMCID: PMC2657292 [Available on 2010/02/01]

H.O. Gulcan and M.W. Duffel. 2008. Pentachlorophenol and other chlorinated phenols are substrates for human hydroxysteroid sulfotransferase hSULT2A1. Chemical Research in Toxicology, 21:1503-8. PMCID: PMC2548291

N.S. Shaikh, S. Parkin, G. Luthe, H.-J. Lehmler. The three-dimensional structure of 3,3′,4,4′-tetrachlorobiphenyl, a dioxin-like polychlorinated biphenyl (PCB), Chemosphere. 2008 February; 70(9): 1694–1698. PMCID: PMC2430941

Y. Song, G. Buettner, S. Parkin, B. Wagner, L.W. Robertson, H.-J. Lehmler. Chlorination Increases the Persistence of Semiquinone Free Radicals Derived from Polychlorinated Biphenyl Hydroquinones and Quinones. Journal of Organic Chemistry 73, 8296-8304 (2008). PMCID: PMC2629131

H.P. Glauert, J.C. Tharappel, S. Banerjee, N. L.S. Chan, I. Kania-Korwel, H.-J. Lehmler, E.Y. Lee, L.W. Robertson, B.T. Spear. Inhibition of the promotion of hepatocarcinogenesis by 2,2',4,4',5,5'-hexachlorobiphenyl (PCB-153) by the deletion of the p50 subunit of NF-kappaB in mice. Toxicol. Appl. Pharmacol. 232, 302-308 (2008). PMCID: PMC2583134

X. Li, S. Parkin, L. W. Robertson, H.-J. Lehmler. 4’-Chlorobiphenyl-4-yl 2,2,2-trichloroethyl sulfate. Acta Cryst. E64, o2464 (2008). Open Access PDF

I. Kania-Korwel, H. Zhao, K. Norstrom, X. Li, K.C. Hornbuckle, H.-J. Lehmler, Simultaneous extraction and clean-up of polychlorinated biphenyls and their metabolites from small tissue samples using pressurized liquid extraction. J. Chromatogr. A 2008 Dec 19;1214(1-2):37-46. Epub 2008 Oct 31. PMID: 19019378 PMCID: PMC2648864 [Available on 2009/12/19]

J. Liu, J. L. Schnoor. Uptake and translocation of lesser-chlorinated polychlorinated biphenyls (PCBs) in whole hybrid poplar plants after hydroponic exposure. Chemosphere,  73(10), November 2008: 1608-1616. PMCID: PMC2668963

Hu, D.; Martinez, A.; Hornbuckle, K.C. Discovery of Non-Aroclor PCB (3,3′-Dichlorobiphenyl) in Chicago Air. Environ. Sci. Technol.; 2008; 42(21); 7873-7877. PMCID: PMC2646757

J.C. Tharappel, H.-J. Lehmler, C. Srinivasan, L.W. Robertson, B.T. Spear, H.P. Glauert. Effect of antioxidant phytochemicals on the hepatic tumor promoting activity of 3,3’,4,4’-tetrachlorobiphenyl (PCB-77). Food Chem. Toxicol. 2008; 46, 3467-3474. PMCID: PMC2597727

Y. Song, B.A. Wagner, H.-J. Lehmler, G.R. Buettner. Semiquinone radicals from oxygenated polychlorinated biphenyls:  Electron paramagnetic resonance studies. Chem. Res. Toxicol. Vol 21 (7), 1359-1367, 2008. PMID: 18549251, ACS AuthorChoice Free Access Full Text

I. Kania-Korwel, S.M. Vyas, Y. Song, H.-J. Lehmler. Gas chromatographic separation of methoxylated polychlorinated biphenyl atropisomers. J. Chromatogr. A 2008:1207, 146-154. PMCID: PMC2579784

V.A. Venkatesha, S. Venkataraman, E.H. Sarsour, A.L. Kalen, G.R. Buettner, L.W. Robertson, H.-J. Lehmler, P.C. Goswami. Catalase ameliorates polychlorinated biphenyl-induced cytotoxicity in non-malignant human breast epithelial cells. Free Radic. Biol. Med. 2008: 45, 1094-1102. PMCID: PMC2614346

I. Kania-Korwel, W. Xie, K.C. Hornbuckle, L.W. Robertson, H.-J. Lehmler. Enantiomeric enrichment of 2,2’,3,3’,6,6’-hexachlorobiphenyl (PCB 136) in mice after induction of CYP enzymes. Arch. Environ. Contam. Toxicol. 2008: 55, 510-517. PMID: 18437444

I. Kania-Korwel, E.G. Hrycay, S.M. Bandiera, H.-J. Lehmler. 2,2',3,3',6,6'-Hexachlorobiphenyl (PCB 136) atropisomers interact enantioselectively with hepatic microsomal cytochrome P450 enzymes. Chem. Res. Toxicol. Vol 21 (6), 1295-1303, 2008. PMCID: PMC2574739

G. Luthe, R. Boy, J. Jacobus, B. Smith, A. Rahaman, L. W. Robertson, G. Ludewig. Xenobiotic Geometry and Media pH determine Cytotoxicity through Solubility. Chem. Res. Toxicol. Vol 21 (5), 1017-1027, 2008. PMID: 18402468

H.J. Lehmler, L. Xu, S.M. Vyas, V.A. Ojogun B.L. Knutson and G. Ludewig. Synthesis, Physicochemical Properties and In Vitro Cytotoxicity of Nicotinic Acid Ester Prodrugs Intended for Pulmonary Delivery Using Perfluorooctyl Bromide as Vehicle. Journal of Pharmaceutics, Vol 353 (1-2), 35-44, 2008. PMCID: PMC2408535

C. Maddox, B. Wang, P.A. Kirby, K. Wang, and G. Ludewig. Mutagenicity of 3-methylcholanthrene, PCB3, and 4-OH-PCB3 in the lung of transgenic BigBlue® rats. Environmental Toxicology and Pharmacology, Vol 25 (2), 260-266, 2008. Abstract

E.L. Gregoraszczuk, A. Rak, G. Ludewig and A. Gasin´ska. Effects of estradiol, PCB3, and their hydroxylated metabolites on proliferation, cell cycle, and apoptosis of human breast cancer cells. Environmental Toxicology and Pharmacology, Vol 25 (2), 227-233, 2008. Abstract

J. Klösener, D. C. Swenson, L. W. Robertson and G. Luthe. Effects of fluoro substitution on 4-bromodiphenyl ether (PBDE 3). Acta Cryst. B64, 108–119 (2008). PMID: 18204217

J.C. Sacco, H.-J. Lehmler, L.W. Robertson, W. Li, and M.O. James. Glucuronidation of polychlorinated biphenylols and UDPGA concentration in channel catfish liver and intestine. Drug Metabolism and Disposition 36, 623–630 (2008). PMID: 18180271

D.N. Stemm, J.C. Tharappel, H.-J Lehmler, C. Srinivasan, J. S. Morris, V.L. Spate, L.W. Robertson, B.T. Spear and H.P. Glauert. Effect of Dietary Selenium on the Promotion of Hepatocarcinogenesis by 3,3’,4,4’-Tetrachlorobiphenyl and 2,2’,4,4’,5,5’-Hexachlorobiphenyl. Exp. Biol. Med. 233, 366–376 (2008). PMID: 18296742

I. Kania-Korwel, K.C. Hornbuckle, L.W. Robertson, and H.-J. Lehmler. Influence of dietary fat on the enantioselective disposition of 2,2',3,3',6,6'-hexachlorobiphenyl (PCB 136) in female mice. Food and Chemical Toxicology 46, 637–644 (2008). PMCID: PMC2289907

I. Kania-Korwel, K. Hornbuckle, L. Robertson, H.-J. Lehmler. Dose-Dependent Enantiomeric Enrichment of 2,2',3,3',6,6'-Hexachlorobiphenyl in Female Mice. Environ Toxicol Chem. 27, 299-305 (2008). PMID: 18348647

L.W. Robertson, W. Sulkowski and B. Hennig, Preface. Special Issue of ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY, FOCUS ON PCBs: RECENT ADVANCES IN ENVIRONMENTAL DISTRIBUTION AND HEALTH EFFECTS, Guest Editors: Larry Robertson, Wieslaw Sulkowski and Bernhard Hennig, Vol. 25, issue 2 March 2008, 127.

G. Luthe, J.A. Jacobus and L.W. Robertson. Receptor interactions by polybrominated diphenyl ethers versus polychlorinated biphenyls: A theoretical structure–activity assessment. Environmental Toxicology and Pharmacology 25, 202-210 (2008). Abstract

G. Ludewig, L. Lehmann, H. Esch and L.W. Robertson, Metabolic activation of PCBs to carcinogens in vivo—A review. Environmental Toxicology and Pharmacology 25, 241-246 (2008). Abstract

H.P. Glauert, J.C. Tharappel, Z. Lu, D. Stemm, S. Banerjee, L.S. Chan, E.Y. Lee, H.-J. Lehmler, L.W. Robertson and B.T. Spear, Role of oxidative stress in the promoting activities of PCBs. Environmental Toxicology and Pharmacology 25, 247-250 (2008). Abstract

J.A. Jacobus, S. Flor, A.J. Klingelhutz, L.W. Robertson and G. Ludewig, 2-(4-chlorophenyl)-1,4-benzoquinone increases the frequency of micronuclei and shortens telomeres. Environmental Toxicology and Pharmacology 25, 267-272 (2008). Abstract

S. Ravoori, P. Ayotte, C. Srinivasan, D. Pereg, L.W. Robertson, G.K. Russell, J. Jeyabalan and R.C. Gupta. DNA damage associated with PCBs in the whole blood cells of Inuit. Environmental Toxicology and Pharmacology 25, 273-276 (2008). Abstract

S. Telu, S. Parkin, L.W. Robertson, H.-J. Lehmler, 1,3,5-Trichloro-2-methoxybenzene. Acta Cryst. E 2008: 64, o424. Full-text PDF

2007

L. W. Robertson, I. Berberian, T. Borges, L. Chen, C.K. Chow, H.P. Glauert, J.G. Filser and H. Thomas. Suppression of peroxisomal enzyme activities and cytochrome P-4504A isozyme expression by congeneric polybrominated and polychlorinated biphenyls. PPAR Research, vol. 2007, Article ID 15481, 5 pages, 2007. PMCID: PMC2220027

M.A. Zettner, S. Flor, G. Ludewig, J. Wagner, L.W. Robertson, L. Lehmann. Quinoid Metabolites of 4-monochlorobiphenyl (PCB3) Induce Gene Mutations in Cultured Chinese Hamster V79 Cells. Toxicological Sciences 100, 88–98 (2007). PMID: 17686921

R.P. Bunaciu, J.C. Tharappel, H.-J. Lehmler, I. Korwel, L.W. Robertson, C. Srinivasan, B.T. Spear, and H.P. Glauert. The Effect of Dietary Glycine on the Hepatic Tumor Promoting Activity of Polychlorinated Biphenyls (PCBs) in Rats. Toxicology 239, 147–155 (2007). PMCID: PMC2063585

G. Luthe, D. C. Swenson and L.W. Robertson. Influence of fluoro-substitution on the planarity of 4-chlorobiphenyl (PCB 3), Acta Crystallographica, Section B: Structural Science 63, 319-327 (2007). PMID: 17374943

H. Sadeghi-aliabadi, K. Chan, H.-J. Lehmler, L.W. Robertson, P.J. O’Brien, Molecular cytotoxic mechanisms of catecholic polychlorinated biphenyl metabolites in isolated rat hepatocytes. Chem.-Biol. Interactions 2007: 167, 184-192. PMID: 17408604

Y. Song, S. Parkin, H.-J. Lehmler. 4-Bromo-2-chloro-1-methoxybenzene. Acta Cryst. E 2007: 63, o2091-o2092.

I. Kania-Korwel, N.S. Shaikh, K.C. Hornbuckle, L.W. Robertson, H.-J. Lehmler. Enantioselective disposition of PCB 136 (2,2’,3,3’,6,6’-Hexachlorobiphenyl) in C57BL/6 mice after oral and intraperitoneal administration.  Chirality 2007: 19, 56-66. PMID: 17089340

L. Lehmann, H.L. Esch, P.A. Kirby, L.W. Robertson, G. Ludewig. 4-Monochlorobiphenyl (PCB3) induces mutations in the livers of transgenic Fisher 344 rats. Carcinogenesis 28, 471-478, 2007. PMID: 16950798

G. Ludewig, H. Esch, L.W. Robertson, Polyhalogenierte Bi- und Terphenyle, Chapter 20, In: Dunkelberg, H., Gebel, T., Hartwig, A. (Editors) Handbuch der Lebensmitteltoxikologie, Wiley-VCH Weinheim, pages 1031-1094, 2007.


2006

Y. Liu, T.I. Apak, H.-J. Lehmler, L.W. Robertson, M.W. Duffel. Hydroxylated polychlorinated biphenyls are substrates and inhibitors of human hydroxysteroid sulfotransferase SULT2A1.  Chem. Res. Toxicol. 2006: 19, 1420-1425. PMID: 17112228

A. Ptak, G. Ludewig, M. Kapiszewska, Z. Magnowska, H.J. Lehmler, L.W. Robertson, E.L. Gregoraszczuk. Induction of cytochromes P-450, caspase-3 and DNA damage by PCB3 and its hydroxylated metabolites in porcine ovary. Toxicology Letters 166, 200-211, 2006. PMID: 16949219

N.S. Shaikh, D.C. Swenson, H.-J. Lehmler. 2,3,6-Trichloroiodobenzene. Acta Cryst. E 2006: 62, o4672-o4673.

S.M. Vyas, S. Parkin, L.W. Robertson, H.-J. Lehmler. 2,5-Dichloro-4'-methoxybiphenyl. Acta Cryst. E 2006: 62, o4162–o4163. Full-text PDF (with permission from publisher)

S.M. Vyas, S. Parkin, L.W. Robertson, H-J. Lehmler. 4 -Chloro-2’,3’-dimethoxybiphenyl. Acta Crystallographica Section E E62, o3639–o3640 (2006). Full-text PDF (with permission from publisher)

J. Strathmann, M. Schwarz, J.C. Tharappel, H. P. Glauert, B.T. Spear, L.W. Robertson, K.E. Appel, A. Buchmann. PCB 153, a non-dioxin-like tumor promoter, selects for ß-Catenin (Catnb) mutated mouse liver tumors. Toxicological Sciences. PMID: 16782779

R.P. Bender, H.-J. Lehmler, L.W. Robertson, G. Ludewig, N. Osheroff. Polychlorinated Biphenyl Quinone Metabolites Poison Human Topoisomerase IIalpha: Altering Enzyme Function by Blocking the N-Terminal Protein Gate. Biochemistry. PMID: 16906772

I. Kania-Korwel, A.W. Garrison, J.K. Avants, K.C. Hornbuckle, L.W. Robertson, W.W. Sulkowski, H.-J. Lehmler, Distribution of Chiral PCBs in Selected Tissues in the Laboratory Rat. Environmental Science & Technology 40, 3704-3710 (2006). Open Access PDF

G. Luthe, P.E.G. Leonards, G.S. Reijerink, H. Liu, J.E. Johansen, L.W. Robertson, Monofluorinated analogues of polybrominated diphenyl ethers (F-PBDEs) as analytical standards: Synthesis, NMR and GC-MS characterization and molecular orbital studies. Environmental Science & Technology 40, 3023-3029 (2006). PMID: 16719106

S. Kunz, H.-J. Schmitz, A. Buchmann, M. Schwarz, B. Schilling, O. Päpke, H.-J. Lehmler, L.W. Robertson and D. Schrenk. Tumor promoting potency of PCBs 28 and 101 in rat liver. Toxicology Letters 164, 133–143 (2006). PMID: 16426774

A. Ptak, G. Ludewig, L.W. Robertson, H.-J. Lehmler and E.L. Gregoraszczuk. In vitro exposure of porcine prepubertal follicles to 4-chlorobiphenyl (PCB3) and its hydroxylated metabolites: effects on sex hormone levels and aromatase activity. Toxicology Letters 164, 113–122 (2006). PMID: 16412591

L.-Q. Wang, H.-J. Lehmler, L.W. Robertson, and M.O. James. Polychlorobiphenylols are selective inhibitors of human phenol sulfotransferase 1A1 with 4-nitrophenol as a substrate. Chem.-Biol. Interactions 159, 235-246 (2006). PMID: 16413005