The Salem Laboratory of Advanced Drug and Gene Delivery

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2009

 

38. A. Petushkov, J. Intra, J.B. Graham, S.C. Larsen, A.K. Salem. Effect of Crystal Size and Surface Functionalization on the Cytotoxicity of Silicalite-1 Nanoparticles. Chemical Research in Toxicology. 2009 [PDF]

37. J. Intra, A.K. Salem. Fabrication, characterization and in vitro evaluation of poly lactic-co-glycolic acid microparticles loaded with polyamidoamine-plasmid DNA dendriplexes for applications in non-viral gene delivery. Journal of Pharmaceutical Sciences. 2009 [PDF]

36. R. Goforth, A.K. Salem, X. Zhu, S. Miles, X.Q. Zhang, J. Lee, A.D. Sandler. Immune stimulatory antigen loaded particles combined with depletion of regulatory T-cells induce potent tumor specific immunity in a mouse model of melanoma. Cancer Immunology, Immunotherapy. 58 (4) 517-30 Apr 2009 [PDF]

35. Y. Krishnamachari and A.K. Salem. Innovative Strategies for Co-delivering Antigens and CpG Oligonucleotides. Advanced Drug Delivery Reviews. 61 (2009) 205-217 [PDF]

34. A.K. Salem and G.J. Weiner. CpG oligonucleotides as Immunotherapeutic Adjuvants: Innovative Applications and Delivery Strategies. Advanced Drug Delivery Reviews. 61 (2009) 193-194 [PDF]

 

2008

 

33. J. Intra, A.K. Salem. Characterization of the transgene expression generated by branched and linear polyethylenimine (PEI)-plasmid DNA nanoparticles in vitro and after intraperitoneal injection in vivo. Journal of Controlled Release (130) 129-138 2008 [PDF]

32. M.E. Pearce, H.Q. Mai, N. Lee, S.C. Larsen, A.K. Salem. Silicalite nanoparticles that promote transgene expression. Nanotechnology (19) 175103 2008 [PDF].

31. J. Intra, J.M Glasgow, H. Q. Mai, A.K. Salem. Pulsatile release of biomolecules from polydimethylsiloxane (PDMS) chips with hydrolytically degradable seals. Journal of Controlled Release (127) 280-287 2008 [PDF].

30. J.D. Clapper, M.E. Pearce, C.A. Guymon, A.K. Salem. Biotinylated biodegradable nanotemplated hydrogel networks for cell interactive applications. Biomacromolecules (9) 1188-1194 2008 [PDF]

29. Y. Krishnamachari, M.E. Pearce, A.K. Salem. Self-assembly of cell-microparticle hybrids. Advanced Materials. 20 (5): 989-993 Mar 2008 [PDF].

28. X.Q. Zhang, J. Intra, A.K. Salem. Comparative study of poly (lactic-co-glycolic acid)-poly ethyleneimine-plasmid DNA microparticles prepared using double emulsion methods. Journal of Microencapsulation. (25) 2008 1-13 [PDF]

27. A.O. Abbas, M.D. Donovan, A.K. Salem. Formulating PLGA particles for plasmid DNA delivery. Journal of Pharmaceutical Sciences.  97(7):2448-61 July 2008 [PDF]

26. A.K. Salem. Biopharmaceutical Drug Design and Development. 2nd Ed. Journal of Medicinal Chemistry 2008

25. A.K. Salem. Frontiers in Drug Design and Discovery. Volume 3. Journal of Medicinal Chemistry. 51(4):1073 2008

24. J.B. Graham, M.E. Pearce, A.K. Salem. Multifunctional, Spherical & Anisotropic Metal and Metal Oxide Nanomaterials in Medical Diagnosis and Therapy. Invited Chapter in "Nanomaterials for the Life Sciences – Volume 3". Wiley-VCH. Edited by Challa Kumar. 2008

23. Y. Krishnamachari, A.K. Salem. Nano-Bio Polymers and Composites. Invited chapter in "Nano-and Biocomposites". Taylor & Francis/CRC Press. Edited by Lau and Hussain. 2008

22. J. Glasgow, A.K. Salem. Stem Cells and Cancer. Invited review for "Encyclopedia of Stem Cell Research". Sage Publications. Edited by Clive Niels Svendsen, Ph.D., Allison D. Ebert, Ph.D. and Geoffrey J. Golson, Ph.D. 2008

21. M.E. Pearce, A.K. Salem. Stem Cell Research in Iowa. Invited review for "Encyclopedia of Stem Cell Research". Sage Publications. Edited by Clive Niels Svendsen, Ph.D., Allison D. Ebert, Ph.D. and Geoffrey J. Golson, Ph.D. 2008

 

2007

20. X.Q. Zhang, J. Intra, A.K. Salem. Conjugation of polyamidoamine dendrimers on biodegradable microparticles for non-viral gene delivery. Bioconjugate Chemistry. 2007 Nov-Dec;18(6):2068-76  [PDF]

19. M.E. Pearce, J.B. Melanko, A.K. Salem. Biomedical applications of multifunctional nanorods. Pharmaceutical Research. 2007 Dec; 24(12):2335-52 [PDF]

18. X.Q. Zhang, C.E. Dahle, G.J. Weiner and A.K. Salem. A comparative study of the antigen-specific immune response induced by co-delivery of CpG ODN and antigen using fusion molecules or biodegradable microparticles. Journal of Pharmaceutical Sciences. 2007 Dec;96(12):3283-92 [PDF]

17. X.Q. Zhang, C.E. Dahle, N.K. Baman, N. Rich, G.J. Weiner and A.K. Salem. Potent antigen-specific immune responses stimulated by co-delivery of CpG ODN and antigens in degradable microparticles. Journal of Immunotherapy, 30 (5): 469-478 July/August 2007 [PDF]

16. A.K. Salem, M. Behlke. siRNA delivery vehicles. Invited Chapter in the Book entitled "RNA Interference: Application to Drug Discovery and Challenges to Pharmaceutical Development". John Wiley & Sons Inc. 2007 Edited by Teresa N. Faria, Siew Peng Ho, and Oliver Steinbach.

15. J.B. Melanko, M.E. Pearce, A.K. Salem. Nanotubes/nanorods/nanofibers/fullerenes for nanoscale drug delivery. Invited Chapter in the Book entitled "Nanotechnology in Drug Delivery". Springer Science/American Association for Pharmaceutical Scientists (AAPS) 2007. Edited by Melgardt M. de Villiers, and Glen S. Kwon. 

14. A.K. Salem, M.K. Salem, H.K. Salem, S. Tapya. New technologies and therapies for cancer. Invited review for the "Encyclopedia of Cancer and Society". Sage Publications 2007 . Edited by J. Geoffrey Golson and Graham A. Colditz.

 

2006

13. J. Sinclair, A.K. Salem. Rapid localized cell trapping on biodegradable polymers using cell surface derivatization and microfluidic networking. Biomaterials. 27 2090-2094 MAR 2006 [PDF]

12. N.K Baman, G.B. Schneider, T.L. Terry, R. Zaharias, A.K. Salem. Spatial control over cell attachment by partial solvent entrapment of poly lysine in microfluidic channels. International Journal of Nanomedicine, 1 (2): APR 2006 [PDF]

11. A.K. Salem. Frontiers in Drug Design and Discovery. Volume 2. Journal of Medicinal Chemistry. 2006 Dec 14;49(25):7555-6.

 

2005

10. A.K. Salem, C.F. Hung, T.W. Kim, T.C. Wu, P.C. Searson, K.W. Leong. Multi-component nanorods for vaccination applications. Nanotechnology. 4 (16): 484-487  APR 2005 [PDF] 

9. A. Hultgren, M. Tanase, E.J. Felton, K. Bhadriraju, A.K. Salem, C.S. Chen, D.H. Reich. Optimization of yield in magnetic cell separations using nickel nanowires of different lengths. Biotechnology Progress. (21): 509-515  APR 2005 [PDF]

8. A.K. Salem and K.W. Leong.  Polymer scaffolds for tissue engineering and gene delivery. Invited Chapter in the Book entitled "Scaffolding in Tissue Engineering". CRC Press 2005 Edited by: Jennifer Elisseeff and Peter X. Ma

 

2004

7. A.K. Salem, M. Chen, J. Hayden, K.W. Leong, and P.C. Searson. Directed assembly of multi-segment Au/Pt/Au nanowires. Nanoletters. 4 (6): 1163-1165 JUN 2004 [PDF]

6. A.K. Salem, J. Chao, K.W. Leong, and P.C. Searson. Receptor mediated self-assembly of multi-component magnetic nanowires. Advanced Materials.  16 (3): 268+ FEB 3 2004 [PDF]

 

2003

5. A.K. Salem, P.C. Searson and K.W. Leong. Multifunctional nanorods for gene delivery. Nature Materials.  Oct 2003, 2, 668-671 [PDF]

4. H.S. Sakhalkar, M.K. Dalal, A.K. Salem, R. Ansari, J. Fu, M.F. Kiani, J. Hanes, K.M. Shakesheff and D.J. Goetz. Leukocyte inspired therapeutic particles that selectively and avidly adhere to inflamed endothelium in vitro and in vivo.  Proceedings of the National Academy of Sciences. 100 (26): 15895-15900 DEC 23 2003 [PDF]

3. A.K. Salem, F.R.A.J. Rose, R. Oreffo, X. Yang, M.C. Davies, J.R. Mitchell, C.J. Roberts, S. Stolnik, S.J.B. Tendler, P.M. Williams and K.M. Shakesheff. Porous polymer and cell composites that self assemble in situ. Advanced Materials. 15 (3): 210-213 FEB 5 2003 [PDF]

 

2002

2. A.K. Salem, R. Stevens, R.G. Pearson, M.C. Davies, S.J.B. Tendler and K.M. Shakesheff. Interactions of 3T3 fibroblasts and endothelial with defined pore features.  Journal of Biomedical Materials Research. 61 (2) 212-217 Aug 2002 [PDF]

 

2001

1. A.K. Salem, S.M. Cannizzaro, M.C. Davies, S.J.B. Tendler, C.J. Roberts, P.M. Williams and K.M. Shakesheff. Synthesis and characterisation of a degradable biotinylated polylactic acid-polyethylene glycol copolymer. Biomacromolecules. Sum 2001, 2, 575-580 [PDF]

 

Peer-reviewed Abstracts

43. The adjuvants, CpG and chitosan, differentially impact CD8+ T cell responses and tumor protection elicited by adenovirus tumor vaccines. C. Lemke, J. Graham, S. Geary, D. Lubaroff, A. Salem. Proceedings of the Autumn Immunology Conference. November 2009

42.  Y. Krishnamachari, C. Lemke, C.E. Dahle, G.J. Weiner, A.K. Salem. PLGA microparticles that co-deliver antigen and toll like receptor ligand adjuvants for applications in cancer immunotherapy. Proceedings of the American Association for Pharmaceutical Scientists. November 2009

41. D. Jiang, A.K. Salem. A novel dextran-polyethylenimine conjugate polymer for polynucleotides delivery. Proceedings of the American Association for Pharmaceutical Scientists. November 2009

40. A. O. Abbas, M. D. Donovan, A. K. Salem. Chitosan-Dextran Sulfate as Vaccine Delivery Systems. Proceedings of the American Association for Pharmaceutical Scientists. November 2009

39. A. O. Abbas, M. D. Donovan, A. K. Salem. Biotinylated Chitosan Applications in Enzyme Immobilization. Proceedings of the American Association for Pharmaceutical Scientists. November 2009

38. A.K. Salem. Innovative Strategies for Co-delivering Antigens and CpG Oligonucleotides. Molecular Therapy: Suppl. 1 2009

37. N. Kim, D. Jiang, A.K. Salem. Polyethylenimine (PEI)-Polyethylene glycol (PEG)-Mannose and Chitosan-PEG-Mannose Tri- Component Vehicles for siRNA Delivery. Proceedings of the Society for Biomaterials Annual Meeting. April 2009

36. J.B. Graham, E. Donahey, D.M. Lubaroff, A.K. Salem. Co-delivery of cationic polymers and adenovirus enhance tumor protection in a murine model of prostate cancer. Abstracts of the American Institute of Chemical Engineers, 2008

35. D. Jiang, N. Kim, A.K. Salem. Polyethylenimine (PEI)-Polyethylene glycol (PEG)-Mannose and Chitosan-PEG-Mannose Tri- Component Vehicles for siRNA Delivery. Proceedings of the American Association for Pharmaceutical Scientists. November 2008

34. J. Intra, J.M Glasgow, H. Q. Mai, A.K. Salem. Pulsatile release of biomolecules from polydimethylsiloxane (PDMS) chips with hydrolytically degradable seals. Proceedings of the American Association for Pharmaceutical Scientists. November 2008

33. J. Intra, A.K. Salem. Characterization of the transgene expression generated by branched and linear polyethylenimine-plasmid DNA nanoparticles in vitro and after intraperitoneal injection in vivo. Proceedings of the American Association for Pharmaceutical Scientists. November 2008

32. Y. Krishnamachari and A.K. Salem. Self-assembly of a cell-microparticle hybrid as a multifunctional drug delivery vehicle. Proceedings of the American Association for Pharmaceutical Scientists. November 2008

31. Y. Krishnamachari and A.K. Salem.Receptor mediated enhancement of the transfection efficiency generated by chitosan-plasmid DNA nanoparticles in vitro. Proceedings of the American Association for Pharmaceutical Scientists. November 2008

30. S.A. Miles, R. Goforth, A.K. Salem, X.Y. Zhu, X.Q. Zhang, J. Lee, A.D. Sandler. Immune stimulatory antigen loaded particles combined with depletion of regulatory T-cells induce potent tumor specific immunity. Journal of Leukocyte Biology 47-47 103 Suppl. S, 2007

29. J. Intra, X.Q. Zhang, A.K. Salem. Conjugation of Polyamidoamine Dendrimers on Biodegradable Microparticles for Non-Viral Gene Delivery. Proceedings of the American Association for Pharmaceutical Scientists. November 2007

28. A. Abbas, M.D. Donovan, A.K. Salem. A Novel Biotinylated Chitosan for Gene Delivery and Tissue Engineering Applications. Proceedings of the American Association for Pharmaceutical Scientists November 2007

27. S.C. Larsen, A.K. Salem, M. Pearce, and N. Lee. Functionalized zeolites for applications in gene delivery. Abstracts of Papers of the American Chemical Society August 2007

26. R. Goforth, A.K. Salem, J. Lee, X. Zhu, S. Miles and A.D. Sandler. Immune stimulatory antigen loaded particles combined with depletion of regulatory T-cells induce tumor specific immunity in a melanoma mouse model. Proceeding of the Keystone Symposia on “The Potent New Anti-Tumor Immunotherapies.” April 2007

25. J. Intra, X.Q. Zhang, A.K. Salem. Preparation and Characterization of Hybrid Poly(lactic-co-glycolic acid)/ Polyethylenimine Particles as Non-Viral Gene Delivery Systems. Proceedings of the American Association for Pharmaceutical Scientists. September 2006

24. X.Q. Zhang, C.E. Dahle, N.K. Baman, X. Zhu, A.D. Sandler, G.J. Weiner, A.K. Salem. Biodegradable Microparticle Delivery of Antigens and Adjuvants Stimulate Potent Anti-Tumor Antigen-Specific Immune Responses. Proceedings of the American Association for Pharmaceutical Scientists. September 2006

23. A.K. Salem. Preparation and Characterization of Hybrid Poly(lactic-co-glycolic acid)/ Polyethylenimine Particles as Non-Viral Gene Delivery Systems. Abstracts of Papers of the American Chemical Society. August 2006

22. A.K. Salem. Utilizing microfluidics for spatial control over cell attachment on biodegradable polymers. Abstracts of Papers of the American Chemical Society. August 2006

21. A.K. Salem. Biodegradable Microparticle Delivery of Antigens and Adjuvants Stimulate Potent Anti-Tumor Antigen-Specific Immune Responses. Abstracts of Papers of the American Chemical Society. August 2006

20. A.K. Salem, A.D. Sandler, G.J. Weiner, X.Q. Zhang, N.K. Baman, X. Zhu, C.E. Dahle. Immunostimulatory antigen loaded microparticles as cancer vaccines. Molecular Therapy:  Suppl. June 2006

19. A.K. Salem. Co-delivery of antigen and adjuvants by particle bombardment of multicomponent metallic nanorods. Abstracts of Papers of the American Chemical Society 230: U1201-U1202 337-COLL AUG 28 2005

18. J. Sinclair, A.K. Salem. Geometric control over cell attachment by microfluidic patterning and sialic acid residue derivatization. Abstracts of Papers of the American Chemical Society 230: U1161-U1161 256-COLL AUG 28 2005

17. N.K. Baman, G.B. Schneider, T.L. Terry, R. Zaharias, A.K. Salem. Localized control over cell binding using a soft lithographic patterning approach to solvent/non-solvent entrapment of poly lysine in pegylated degradable substrates. Abstracts of Papers of the American Chemical Society, 230: U1161-U1161 257-COLL AUG 28 2005

16. T.L. Terry, V.G.J. Rodgers, A.K. Salem. Preparing Porous Polymeric Particles by Localized Solvent Implosion for Pulmonary Drug Delivery Applications. Abstracts of the American Institute of Chemical Engineers, 2005

15. M. Chen, R. Ravi, A.K. Salem, P.C. Searson. Receptor directed self-assembly of multicomponent nanowires. Abstracts of Papers of the American Chemical Society 228: U787-U787 076-INOR Part 1, AUG 22 2004

14. C.I. Fisher, F. Peng, A.K. Salem , S.C. Kuo. Micropatterning of ActA to study Actin-Based Motility. Biophysical Journal 86 (1): 71A-71A Part 2 Suppl. S JAN 2004

13. A.K. Salem, P.C. Searson, K.W. Leong. Multifunctional Nanorods for Gene Delivery. Mat. Res. Soc. Symp. Proc. Vol. EXS-1 I6.5.1, 2003

12. K.W. Leong, P.C. Searson, A.K. Salem. Nanorods for Gene Delivery. Proceedings of the Singapore Materials Research Society. (2003) 

11. H.S. Sakhalkar, A.K. Salem, K.M. Shakesheff, T. Morita, J. Hanes, R. Ansari M.F. Kiani, D.J. Goetz. Leukocyte Inspired Therapeutic Particles that Selectively and Avidly Adhere to Inflamed Endothelium in Vitro and in Vivo. BMES Bulletin (2003)

10. A.K. Salem, P.C. Searson, K.W. Leong. Multifunctional Nanorods for Gene Delivery. Proceedings of DARPA Biomagnetics (2003)

9. K.M. Shakesheff, M. Whitaker, F.R.A.J. Rose, A.K. Salem, S.M. Howdle, P. DeBank, B. Kellam. Controlled Release Systems for Regenerative Medicine. Proceed. Intern. Symp. Control. Rel. Bioact. Mater. (2003)

8. H.S. Sakhalkar, A.K. Salem, K.M. Shakesheff, T. Morita, J. Hanes, R. Ansari,  M.F. Kiani, D.J. Goetz. Leukocyte Inspired Therapeutic Particles that Selectively and Avidly Adhere to Inflamed Endothelium in Vitro and in Vivo. Proceed. Intern. Symp. Control. Rel. Bioact. Mater. 30:507 (2003)

7. K.M. Shakesheff, M. Whitaker, F.R.A.J. Rose, A.K. Salem, S.M. Howdle, P. DeBank, B. Kellam. Delivering Protein and Cell Therapeutics to Promote Tissue Regeneration. Proceed. Intern. Winter. Symp. Control. Rel. Bioact. Mater. (2003)

6. H.S. Sakhalkar, A.K. Salem, K.M. Shakesheff, T. Morita, J. Hanes, R. Ansari,  M. F. Kiani, D. J. Goetz. Targeting Biodegradable Particles to Select Segments of the Endothelium in Vitro and in Vivo. Proceed. Intern. Winter. Symp. Control. Rel. Bioact. Mater. (Winter 2003)

5. A.K. Salem, F.R.A.J. Rose, M.C. Davies, J.R. Mitchell, C.J. Roberts, S. Stolnik, S.J.B. Tendler, P.M. Williams and K.M. Shakesheff. The Development of an In Situ Solidifying Degradable Scaffold through the Utilisation of the Biotin-Avidin Binding Mechanism. Proceed. Intern. Symp. Control. Rel. Bioact. Mater. 28:287-288 (2001)

4. A.K. Salem. A Polymer Designed For Tissue Engineering and Drug Delivery. Proceedings of Chemistry 2000. “Highlights of chemistry research and R&D by younger chemists in 2000” at The Royal Society, 6 Carlton House Terrace, London 21st November 2000 .

3. A.K. Salem, R. Stevens, R.G. Pearson, M.C. Davies, S.J.B. Tendler and K.M. Shakesheff. Proceedings of the Second Annual Symposium of the Tissue and Cell Engineering Society 18th-19th September 2000 , University of Nottingham - Fibroblast and Bovine Aortic Endothelial cell behaviour over a range of defined pore features.

2. A.K. Salem, S.M. Cannizarro, M.C. Davies, S.J.B. Tendler, C.J. Roberts, P.M. Williams and K.M. Shakesheff. Proceedings of the Fourth International Symposium on Polymer Therapeutics: From Laboratory to Clinical Practice 5-7th January 2000 at The School of Pharmacy , University of London . Synthesis and Characterisation of a Biotinylated Degradable Polylactide-Polyethylene glycol Copolymer.  

1. R.G. Pearson, A.K. Salem, N. Patel, K.M. Shakesheff, M.C. Davies, S.J.B. Tendler, C.J. Roberts and P.M. Williams. Proceedings of the First Scientific Meeting of the Tissue and Cell Engineering Society 5th-6th July 1999 at Imperial College School of Medicine.  Development of Bio-interactive Materials For Peripheral Nerve Regeneration.

 

 

 

 

 

 
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Last updated: May 26, 2009. © Copyright 2008