The Salem Laboratory
of Advanced Drug and Gene Delivery
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| Publications 2009
38. A. Petushkov, J. Intra, J.B. Graham, S.C. Larsen, A.K. Salem. Effect of Crystal Size and Surface Functionalization on the Cytotoxicity of Silicalite-1 Nanoparticles. Chemical Research in Toxicology. 2009 [PDF] 37. J. Intra, A.K. Salem. Fabrication, characterization and in vitro evaluation of poly lactic-co-glycolic acid microparticles loaded with polyamidoamine-plasmid DNA dendriplexes for applications in non-viral gene delivery. Journal of Pharmaceutical Sciences. 2009 [PDF] 36. R. Goforth, A.K. Salem, X. Zhu, S. Miles, X.Q. Zhang, J. Lee, A.D. Sandler. Immune stimulatory antigen loaded particles combined with depletion of regulatory T-cells induce potent tumor specific immunity in a mouse model of melanoma. Cancer Immunology, Immunotherapy. 58 (4) 517-30 Apr 2009 [PDF] 35. Y. Krishnamachari and A.K. Salem. Innovative Strategies for Co-delivering Antigens and CpG Oligonucleotides. Advanced Drug Delivery Reviews. 61 (2009) 205-217 [PDF] 34. A.K. Salem and G.J. Weiner. CpG oligonucleotides as Immunotherapeutic Adjuvants: Innovative Applications and Delivery Strategies. Advanced Drug Delivery Reviews. 61 (2009) 193-194 [PDF]
2008
33. J. Intra, A.K. Salem. Characterization of the transgene expression generated by branched and linear polyethylenimine (PEI)-plasmid DNA nanoparticles in vitro and after intraperitoneal injection in vivo. Journal of Controlled Release (130) 129-138 2008 [PDF] 32. M.E. Pearce, H.Q. Mai, N. Lee, S.C. Larsen, A.K. Salem. Silicalite nanoparticles that promote transgene expression. Nanotechnology (19) 175103 2008 [PDF]. 31. J. Intra, J.M Glasgow, H. Q. Mai, A.K. Salem. Pulsatile release of biomolecules from polydimethylsiloxane (PDMS) chips with hydrolytically degradable seals. Journal of Controlled Release (127) 280-287 2008 [PDF]. 30. J.D. Clapper, M.E. Pearce, C.A. Guymon, A.K. Salem. Biotinylated biodegradable nanotemplated hydrogel networks for cell interactive applications. Biomacromolecules (9) 1188-1194 2008 [PDF] 29. Y. Krishnamachari, M.E. Pearce, A.K. Salem. Self-assembly of cell-microparticle hybrids. Advanced Materials. 20 (5): 989-993 Mar 2008 [PDF]. 28. X.Q. Zhang, J. Intra, A.K. Salem. Comparative study of poly (lactic-co-glycolic acid)-poly ethyleneimine-plasmid DNA microparticles prepared using double emulsion methods. Journal of Microencapsulation. (25) 2008 1-13 [PDF] 27. A.O. Abbas, M.D. Donovan, A.K. Salem. Formulating PLGA particles for plasmid DNA delivery. Journal of Pharmaceutical Sciences. 97(7):2448-61 July 2008 [PDF] 26. A.K. Salem. Biopharmaceutical Drug Design and Development. 2nd Ed. Journal of Medicinal Chemistry 2008 25. A.K. Salem. Frontiers in Drug Design and Discovery. Volume 3. Journal of Medicinal Chemistry. 51(4):1073 2008 24. J.B. Graham, M.E. Pearce, A.K. Salem. Multifunctional, Spherical & Anisotropic Metal and Metal Oxide Nanomaterials in Medical Diagnosis and Therapy. Invited Chapter in "Nanomaterials for the Life Sciences – Volume 3". Wiley-VCH. Edited by Challa Kumar. 2008 23. Y. Krishnamachari, A.K. Salem. Nano-Bio Polymers and Composites. Invited chapter in "Nano-and Biocomposites". Taylor & Francis/CRC Press. Edited by Lau and Hussain. 2008 22. J. Glasgow, A.K. Salem. Stem Cells and Cancer. Invited review for "Encyclopedia of Stem Cell Research". Sage Publications. Edited by Clive Niels Svendsen, Ph.D., Allison D. Ebert, Ph.D. and Geoffrey J. Golson, Ph.D. 2008 21. M.E. Pearce, A.K. Salem. Stem Cell Research in Iowa. Invited review for "Encyclopedia of Stem Cell Research". Sage Publications. Edited by Clive Niels Svendsen, Ph.D., Allison D. Ebert, Ph.D. and Geoffrey J. Golson, Ph.D. 2008
2007 20. X.Q. Zhang, J. Intra, A.K. Salem. Conjugation of polyamidoamine dendrimers on biodegradable microparticles for non-viral gene delivery. Bioconjugate Chemistry. 2007 Nov-Dec;18(6):2068-76 [PDF] 19. M.E. Pearce, J.B. Melanko, A.K. Salem. Biomedical applications of multifunctional nanorods. Pharmaceutical Research. 2007 Dec; 24(12):2335-52 [PDF] 18. X.Q. Zhang, C.E. Dahle, G.J. Weiner and A.K. Salem. A comparative study of the antigen-specific immune response induced by co-delivery of CpG ODN and antigen using fusion molecules or biodegradable microparticles. Journal of Pharmaceutical Sciences. 2007 Dec;96(12):3283-92 [PDF] 17. X.Q. Zhang, C.E. Dahle, N.K. Baman, N. Rich, G.J. Weiner and A.K. Salem. Potent antigen-specific immune responses stimulated by co-delivery of CpG ODN and antigens in degradable microparticles. Journal of Immunotherapy, 30 (5): 469-478 July/August 2007 [PDF] 16. A.K. Salem, M. Behlke. siRNA delivery vehicles. Invited Chapter in the Book entitled "RNA Interference: Application to Drug Discovery and Challenges to Pharmaceutical Development". John Wiley & Sons Inc. 2007 Edited by Teresa N. Faria, Siew Peng Ho, and Oliver Steinbach. 15. J.B. Melanko, M.E. Pearce, A.K. Salem. Nanotubes/nanorods/nanofibers/fullerenes for nanoscale drug delivery. Invited Chapter in the Book entitled "Nanotechnology in Drug Delivery". Springer Science/American Association for Pharmaceutical Scientists (AAPS) 2007. Edited by Melgardt M. de Villiers, and Glen S. Kwon. 14. A.K. Salem, M.K. Salem, H.K. Salem, S. Tapya. New technologies and therapies for cancer. Invited review for the "Encyclopedia of Cancer and Society". Sage Publications 2007 . Edited by J. Geoffrey Golson and Graham A. Colditz.
2006 13. J. Sinclair, A.K. Salem. Rapid localized cell trapping on biodegradable polymers using cell surface derivatization and microfluidic networking. Biomaterials. 27 2090-2094 MAR 2006 [PDF] 12. N.K Baman, G.B. Schneider, T.L. Terry, R. Zaharias, A.K. Salem. Spatial control over cell attachment by partial solvent entrapment of poly lysine in microfluidic channels. International Journal of Nanomedicine, 1 (2): APR 2006 [PDF] 11. A.K. Salem. Frontiers in Drug Design and Discovery. Volume 2. Journal of Medicinal Chemistry. 2006 Dec 14;49(25):7555-6.
2005 10. A.K. Salem, C.F. Hung, T.W. Kim, T.C. Wu, P.C. Searson, K.W. Leong. Multi-component nanorods for vaccination applications. Nanotechnology. 4 (16): 484-487 APR 2005 [PDF] 9. A. Hultgren, M. Tanase, E.J. Felton, K. Bhadriraju, A.K. Salem, C.S. Chen, D.H. Reich. Optimization of yield in magnetic cell separations using nickel nanowires of different lengths. Biotechnology Progress. (21): 509-515 APR 2005 [PDF] 8. A.K. Salem and K.W. Leong. Polymer scaffolds for tissue engineering and gene delivery. Invited Chapter in the Book entitled "Scaffolding in Tissue Engineering". CRC Press 2005 Edited by: Jennifer Elisseeff and Peter X. Ma
2004 7. A.K. Salem, M. Chen, J. Hayden, K.W. Leong, and P.C. Searson. Directed assembly of multi-segment Au/Pt/Au nanowires. Nanoletters. 4 (6): 1163-1165 JUN 2004 [PDF] 6. A.K. Salem, J. Chao, K.W. Leong, and P.C. Searson. Receptor mediated self-assembly of multi-component magnetic nanowires. Advanced Materials. 16 (3): 268+ FEB 3 2004 [PDF]
2003 5. A.K. Salem, P.C. Searson and
K.W. Leong.
Multifunctional nanorods for gene delivery. Nature Materials.
Oct 2003, 2, 668-671 4. H.S. Sakhalkar,
M.K. Dalal, A.K.
Salem, R. Ansari, J. Fu, M.F. Kiani, J. Hanes, K.M. Shakesheff and
D.J. Goetz. Leukocyte inspired therapeutic particles that selectively and avidly
adhere to inflamed endothelium in vitro and in vivo.
Proceedings of the
3. A.K. Salem, F.R.A.J. Rose, R. Oreffo, X. Yang, M.C. Davies, J.R. Mitchell, C.J. Roberts, S. Stolnik, S.J.B. Tendler, P.M. Williams and K.M. Shakesheff. Porous polymer and cell composites that self assemble in situ. Advanced Materials. 15 (3): 210-213 FEB 5 2003 [PDF]
2002 2. A.K. Salem, R. Stevens,
R.G. Pearson, M.C.
Davies, S.J.B. Tendler and K.M. Shakesheff. Interactions of 3T3 fibroblasts and
endothelial with defined pore features. Journal
of Biomedical Materials Research. 61 (2) 212-217 Aug 2002
2001 1. A.K. Salem, S.M. Cannizzaro, M.C. Davies, S.J.B.
Tendler, C.J. Roberts, P.M. Williams and K.M. Shakesheff. Synthesis and
characterisation of a degradable biotinylated polylactic acid-polyethylene
glycol copolymer. Biomacromolecules. Sum 2001, 2, 575-580
Peer-reviewed Abstracts 43. The adjuvants, CpG and chitosan, differentially impact CD8+ T cell responses and tumor protection elicited by adenovirus tumor vaccines. C. Lemke, J. Graham, S. Geary, D. Lubaroff, A. Salem. Proceedings of the Autumn Immunology Conference. November 2009 42.
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38. A.K. Salem. Innovative Strategies for Co-delivering Antigens and CpG Oligonucleotides. Molecular Therapy: Suppl. 1 2009 37. N. Kim, D. Jiang, A.K. Salem. Polyethylenimine (PEI)-Polyethylene glycol (PEG)-Mannose and Chitosan-PEG-Mannose Tri- Component Vehicles for siRNA Delivery. Proceedings of the Society for Biomaterials Annual Meeting. April 2009 36. J.B. Graham, E. Donahey, D.M. Lubaroff, A.K. Salem. 35. D. Jiang, N. Kim,
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32. Y. Krishnamachari and A.K. Salem. 31. 30.
29. J. Intra, X.Q. Zhang, A.K. Salem. Conjugation of Polyamidoamine Dendrimers on Biodegradable Microparticles for Non-Viral Gene Delivery. Proceedings of the American Association for Pharmaceutical Scientists. November 2007 28. A. Abbas, M.D. Donovan, A.K. Salem. A Novel Biotinylated Chitosan for Gene Delivery and Tissue Engineering Applications. Proceedings of the American Association for Pharmaceutical Scientists November 2007 27. S.C. Larsen, A.K. Salem, M. Pearce, and N. Lee. Functionalized zeolites for applications in gene delivery. Abstracts of Papers of the American Chemical Society August 2007 26. R. Goforth, A.K. Salem, J. Lee, X. Zhu, S. Miles and A.D. Sandler. Immune stimulatory antigen loaded particles combined with depletion of regulatory T-cells induce tumor specific immunity in a melanoma mouse model. Proceeding of the Keystone Symposia on “The Potent New Anti-Tumor Immunotherapies.” April 2007 25. J. Intra, X.Q. Zhang, A.K. Salem. Preparation and Characterization of Hybrid Poly(lactic-co-glycolic acid)/ Polyethylenimine Particles as Non-Viral Gene Delivery Systems. Proceedings of the American Association for Pharmaceutical Scientists. September 2006 24. X.Q. Zhang, C.E. Dahle, N.K. Baman, X. Zhu, A.D. Sandler, G.J. Weiner, A.K. Salem. Biodegradable Microparticle Delivery of Antigens and Adjuvants Stimulate Potent Anti-Tumor Antigen-Specific Immune Responses. Proceedings of the American Association for Pharmaceutical Scientists. September 2006 23. A.K. Salem. Preparation and Characterization of Hybrid Poly(lactic-co-glycolic acid)/ Polyethylenimine Particles as Non-Viral Gene Delivery Systems. Abstracts of Papers of the American Chemical Society. August 2006 22. A.K. Salem. Utilizing microfluidics for spatial control over cell attachment on biodegradable polymers. Abstracts of Papers of the American Chemical Society. August 2006 21. A.K. Salem. Biodegradable Microparticle Delivery of Antigens and Adjuvants Stimulate Potent Anti-Tumor Antigen-Specific Immune Responses. Abstracts of Papers of the American Chemical Society. August 2006 20. A.K. Salem, A.D. Sandler, G.J. Weiner, X.Q. Zhang, N.K. Baman, X. Zhu, C.E. Dahle. Immunostimulatory antigen loaded microparticles as cancer vaccines. Molecular Therapy: Suppl. June 2006 19. A.K. Salem. Co-delivery of antigen and adjuvants by particle bombardment of multicomponent metallic nanorods. Abstracts of Papers of the American Chemical Society 230: U1201-U1202 337-COLL AUG 28 2005 18. J. Sinclair, A.K. Salem. Geometric control over cell attachment by microfluidic patterning and sialic acid residue derivatization. Abstracts of Papers of the American Chemical Society 230: U1161-U1161 256-COLL AUG 28 2005 17. N.K. Baman, G.B. Schneider, T.L. Terry, R. Zaharias, A.K. Salem. Localized control over cell binding using a soft lithographic patterning approach to solvent/non-solvent entrapment of poly lysine in pegylated degradable substrates. Abstracts of Papers of the American Chemical Society, 230: U1161-U1161 257-COLL AUG 28 2005 16. T.L. Terry, V.G.J. Rodgers, A.K. Salem. Preparing Porous Polymeric Particles by Localized Solvent Implosion for Pulmonary Drug Delivery Applications. Abstracts of the American Institute of Chemical Engineers, 2005 15. M. Chen, R. Ravi, A.K. Salem, P.C. Searson. Receptor directed self-assembly of multicomponent nanowires. Abstracts of Papers of the American Chemical Society 228: U787-U787 076-INOR Part 1, AUG 22 2004 14. C.I. Fisher, F. Peng, A.K. Salem
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13. A.K. Salem, P.C. Searson, K.W. Leong. Multifunctional Nanorods for Gene Delivery. Mat. Res. Soc. Symp. Proc. Vol. EXS-1 I6.5.1, 2003 12. K.W. Leong, P.C. Searson, A.K. Salem. Nanorods for Gene Delivery. Proceedings of the Singapore Materials Research Society. (2003) 11. H.S. Sakhalkar, A.K. Salem, K.M. Shakesheff, T.
Morita, J. Hanes, R. Ansari M.F. Kiani, D.J. Goetz.
Leukocyte
Inspired Therapeutic Particles that Selectively and Avidly Adhere to Inflamed
Endothelium in Vitro and in Vivo. BMES
Bulletin (2003) 10. A.K. Salem, P.C. Searson, K.W. Leong.
Multifunctional Nanorods for Gene Delivery.
Proceedings of DARPA Biomagnetics (2003) 9. K.M. Shakesheff, M. Whitaker, F.R.A.J. Rose, A.K.
Salem, S.M. Howdle, P. DeBank, B. Kellam. Controlled Release Systems for
Regenerative Medicine. Proceed. Intern. Symp. Control. Rel. Bioact. Mater.
(2003) 8. H.S.
Sakhalkar, A.K. Salem, K.M. Shakesheff, T. Morita, J. Hanes, R. Ansari,
M.F. Kiani, D.J. Goetz. Leukocyte Inspired
Therapeutic Particles that Selectively and Avidly Adhere to Inflamed Endothelium
in Vitro and in Vivo. Proceed. Intern. Symp. Control. Rel.
Bioact. Mater. 30:507 (2003) 7. K.M. Shakesheff, M. Whitaker, F.R.A.J. Rose, A.K.
Salem, S.M. Howdle, P. DeBank, B. Kellam. Delivering Protein and Cell
Therapeutics to Promote Tissue Regeneration. Proceed. Intern. Winter. Symp.
Control. Rel. Bioact. Mater. (2003) 6. H.S. Sakhalkar, A.K. Salem, K.M. Shakesheff, T. Morita, J. Hanes, R. Ansari, M. F. Kiani, D. J. Goetz. Targeting Biodegradable Particles to Select Segments of the Endothelium in Vitro and in Vivo. Proceed. Intern. Winter. Symp. Control. Rel. Bioact. Mater. (Winter 2003) 5. A.K. Salem, F.R.A.J. Rose, M.C. Davies, J.R.
Mitchell, C.J. Roberts, S. Stolnik, S.J.B. Tendler, P.M. Williams and K.M.
Shakesheff. The Development of an In Situ Solidifying Degradable
Scaffold through the Utilisation of the Biotin-Avidin Binding Mechanism. Proceed.
Intern. Symp. Control. Rel. Bioact. Mater. 28:287-288 (2001) 4. A.K. Salem. A Polymer Designed For Tissue Engineering and Drug
Delivery. 3. A.K. Salem, R. Stevens, R.G. Pearson, M.C.
Davies, S.J.B. Tendler and K.M. Shakesheff. Proceedings of the Second Annual
Symposium of the Tissue and Cell Engineering Society
2. A.K. Salem, S.M. Cannizarro, M.C. Davies, S.J.B.
Tendler, C.J. Roberts, P.M. Williams and K.M. Shakesheff. Proceedings of the
Fourth International Symposium on Polymer Therapeutics: From Laboratory to
Clinical Practice
1. R.G. Pearson, A.K. Salem, N. Patel, K.M.
Shakesheff, M.C. Davies, S.J.B. Tendler, C.J. Roberts and P.M. Williams. Proceedings of the First Scientific Meeting of the Tissue and Cell Engineering
Society
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